Qunupristin/Dalfopristin ( Synercid)

Question 1

what is the mechanism of action for Quinupristin/Dalfopritsin (Synercid)

Answer 1

irreversibly binds to 50S

Question 2

what is the specific mechanism of action for quinupristin

Answer 2

inhibits chain formation resulting in early termination

Question 3

what is the specific mechanism of action for dalfopristin

Answer 3

inhibits peptide elongation by interfering with peptidyl transferase

Question 4

individually what type of bacteria are quinuprisitin and dalfropristin

Answer 4

-cidal

Question 5

what type of drug is the combination of quinupristin and dalfropristin ( synercid)

Answer 5

-static

Question 6

what bacteria does Synercid cover

Answer 6

MRSA
PCN-resistant strep pneumo
VRE ( not E. faecalis) 
anaerobes
some gram (-)

Question 7

how is Synercid administered

Answer 7

IV only (PICC or central line)