Carbapenems

Question 1

impenem

Answer 1

carboecephem beta-lactam agent; sulfur replaced by carbon

Question 2

how do carbapenems work?

Answer 2

bind to PBP resulting in a cidal effect

Question 3

where is imipenem metabolized and how is this prevented

Answer 3

• renal by brush border enzyme

- cilastin

Question 4

what stands out in carbapenems about the ertapenem

Answer 4

longest 1/2 life

Question 5

what adverse effects does imipenem have

Answer 5

seizures in patients in epilepsy or not adjusted renal function

Question 6

carbapenems have a cross reactivity with what

Answer 6

penicllin

Question 7

leukopenia

Answer 7

decrease white blood cell count

Question 8

what hematologic adverse effects does carbapenems have

Answer 8

anaemia
leukopenia
thrombocytopneia

Question 9

what do imipenem, meropenem, doripenem cover

Answer 9

staph, strep, enterococcus’

• space
• anaerobes
• ESBL oragnisms

Question 10

what does ertapenem cover

Answer 10

staph, strep
anaerobes
ESBL organsisms

Question 11

what are carbapenems used

Answer 11

serious nosocomial infection caused by mutlple organisms or ESBL producing bacteria