Streptococcal pyogenes Flashcards
Strep Pyogenes is what type of gram bacteria
positive
Does it work with or without oxygen
facultative anaerobe
Name 2 surface proteins of strep pyogenes
M- protein
F-protien
What does M and F proteins help to establish
helps establishing infection
opsonization
bacteria are targeted for destruction by an immune cell known as a phagocyte
what makes the M protein a virulence factor
inhibits opsonization
immunogenic
what makes the F protein a virulence factor
mediate adherence to mucoepithelium via binding fibronectin
what makes the C5a peptidase a virulence factor
reduces inflammation mediated by C5a
what makes the streptokinase a virulence factor
promotes bacterial spread into tissues by breaking down blood clots
what makes the streptolysin O and S a virulence factor
lyse RBC by activating plasmin
what is the difference between streptolyisn S and O
O: immunogenic
S: nonimmunogenic
What does ASO test for?
blood test to measure amount of antibodies against streptolysin O
what makes the DNase a virulence factor
- depolymerizes cell with no nucleus
- aids in bacterial spread
what is Anti-DNase B
marker of cutaneous group 1 streptococcal infections
what is the number one causative agent from GAS
cellulitis
Erysipelas
inflammation of cheeks
impetigo
crusting with pus
when does one get acute glomerular nephritis
post presence of Group A streptococcus
- post-pharyngitis
- post-skin infection
why is there blood in urine for acute glomerular nephritis
- immune complex stuck in basement membrane
- activates complement
- bring neutrophils
- hole in basement membrane
why is there facial edema in acute glomerular nephritis
- inflammation
- scar formation
- closes fenstrated basement membrane
- facial edema
when does one get acute rheumatic fever
post pharyngitis
Where is GAS normally found
skin and oropharynx
what can cause a GAS infection
penetration of tissue
how is GAS transmitted
person to person
