Allman review Flashcards
what are the gram positive bacteria
staph
strep
enterococcus
what are the atypical bacteria
chlamydia
mycoplasma
legionella
why are atypical drugs called atypical
they don’t take up red or blue dye, so present atypically
what are the anaerobe bugs
peptostreptococcus
bacteroides
clostridium
what are the gram negative PIddly drugs
haemophilus moraxella (M.cat) salmonella shigella morganella
what are gram negative bugs that are piddly but also fence bugs
neisseria
providencia
why are FENCE bugs called fence bugs
sometimes they are really hard to treat or very easy
what is a pan culture
culture everything
blood, urine, sputum
what acronym is used for fence bugs
PEK
proteus
E. coli
klebsiella
where are SPACE bugs found
hospitals or nursing homes
when is broad specturm therapy used
- when we don’t know what the bug is
synergy
1+1+5
time dependent kill? what is minimum dosing
time above MIC
minimum of 40-50% dosing
what do you want in concentration dependent kill
high peak
get post-anti-biotic effect
-10 times MIC for peak
Name two dugs that have concentration dependent kill
aminoglycosides
fluroquinolones
what are the two penicillins that cover psuedomonas
pipercillin
ticarcylin
what cephalosporins cover psuedomonas
4th generation - cepefime 3rd genertaion (antipseudomal) - ceftazidime
what does cefoxitin and cefetetan cover
anaerobes
which cephalosporin covers MRSA
5th generation: ceftaroline
which carbapenems cover pseudomonas
imipenem
meropenim
doripenim
MOA fluroquinolones
work on DNA gyrase
aminoglycosides MOA
work on 30S
what drug is taken orally for gut decontamination
niomyocin
Niomyocin high peak has what adverse effect
high ototoxicity
Niomyocin too high of troughs is associated with what adverse effect
high nephrotoxicity
what other drug beside nicomyosin also exhibits high troughs and high peak side effects
vancomyosin
what is the infusion related syndrome with vancyomyocin
Red man’s sydnrome
why is methacillin off the market
severe damage to kidneys
interstitial nephritis
ampicillin is drug choice for what bacteria
strep enterococcus H. flu salmonella/shigella PEK
what does aminoglycosides cover
gram (-)
synergy for enterococcus
what does vancomycin cover
graph (+) except VRE
MRSA
Linezolid covers what
MRSA
VRE
what is the drug drug interaction with Linezolid
serotonin uptake inhibitor
causes serotonin storm because it is MOA inhibitor
what is Mupricin used for
MRSA eradication
topical only
fosfomyocin is good for what type of disease state
UTI
