Treatment Of Parkinson Disease Flashcards by Jhaunte Braithwaite

Q

Describe Parkinson’s disease

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Q

Describe the etiology of Parkinson’s disease

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Q

What’s the mechanism of dopamine synthesis?

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Q

What’s the rate limiting step of dopamine synthesis?

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Q

Why is it possible to increase amounts of substrates for dopamine?

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Q

What are the chemical impacts of D1 and D2 receptors?

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Q

What are the benefits of dopaminergic receptors?

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Q

Summarize the pathophysiology of Parkinson’s disease

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Q

Describe the loss of neurons of the substantia nigra

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Q

Describe the strategy of treatment for Parkinson’s disease

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Q

What are the categories of drugs used in Parkinson’s disease?

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Q

What is the main dopamine precursor?

A

Levodopa

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Q

What is the structure of levodopa?

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Q

What is the purpose of levodopa?

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Q

What’s the mechanism of action of levodopa?

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Q

What is Carbidopa?

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Q

What does carbidopa do?

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Q

What are the pharmacokinetics levodopa?

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Q

What’s the metabolism of levodopa?

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Q

What are the clinical uses of levodopa?

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What are the adverse effects of levodopa?

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What are the fluctuations in response to levodopa?

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What’s the interactions & contraindications of levodopa?

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Q

Describe the Coadministration levodopa

A

What are the categories of dopamine receptor agonists?

What is Bromocriptine?

What are Pramipexole & Ropinirole?

What is rotigotine?

What are the GI effects of dopamine agonists?

What are the cardiovascular effects of dopamine agonists?

What are the adverse effects of dopamine agonists for dyskinesias?

What are the mental disturbances of dopamine agonists?

Describe the miscellaneous adverse effects dopamine agonists

What are the drug interactions of dopamine agonists?

What are the contraindications dopamine agonists?

Describe apomorphine

What are the inhibitors of dopamine metabolism?

Discuss the use and mechanism of Selegiline

What is rasagiline?

What are the drug interactions of Monoamine oxidase inhibitors?

What are the COMT inhibitors?

What is the inhibition of dopa decarboxylase?

How do carbidopa, tolcapone, and entacapone interact?

What are the COMT Inhibitors?

What are the adverse effects of COMT INHIBITORS?

Describe amantadine

Describe amantadine adverse effects

What are the useful antimuscuranics?

Describe choice of treatment for Parkinson’s disease