Treatment Of Parkinson Disease Flashcards by Jhaunte Braithwaite | Brainscape

Q

Describe Parkinson’s disease

A

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Q

Describe the etiology of Parkinson’s disease

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Q

What’s the mechanism of dopamine synthesis?

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Q

What’s the rate limiting step of dopamine synthesis?

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Q

Why is it possible to increase amounts of substrates for dopamine?

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Q

What are the chemical impacts of D1 and D2 receptors?

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Q

What are the benefits of dopaminergic receptors?

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Q

Summarize the pathophysiology of Parkinson’s disease

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Q

Describe the loss of neurons of the substantia nigra

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Q

Describe the strategy of treatment for Parkinson’s disease

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Q

What are the categories of drugs used in Parkinson’s disease?

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Q

What is the main dopamine precursor?

A

Levodopa

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Q

What is the structure of levodopa?

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Q

What is the purpose of levodopa?

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Q

What’s the mechanism of action of levodopa?

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Q

What is Carbidopa?

A

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Q

What does carbidopa do?

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Q

What are the pharmacokinetics levodopa?

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Q

What’s the metabolism of levodopa?

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Q

What are the clinical uses of levodopa?

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Q

What are the adverse effects of levodopa?

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Q

What are the fluctuations in response to levodopa?

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Q

What’s the interactions & contraindications of levodopa?

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Q

Describe the Coadministration levodopa

A

Q

What are the categories of dopamine receptor agonists?

A

Q

What is Bromocriptine?

A

Q

What are Pramipexole & Ropinirole?

A

Q

What is rotigotine?

A

Q

What are the GI effects of dopamine agonists?

A

Q

What are the cardiovascular effects of dopamine agonists?

A

Q

What are the adverse effects of dopamine agonists for dyskinesias?

A

Q

What are the mental disturbances of dopamine agonists?

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Q

Describe the miscellaneous adverse effects dopamine agonists

A

Q

What are the drug interactions of dopamine agonists?

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Q

What are the contraindications dopamine agonists?

A

Q

Describe apomorphine

A

Q

What are the inhibitors of dopamine metabolism?

A

Q

Discuss the use and mechanism of Selegiline

A

Q

What is rasagiline?

A

Q

What are the drug interactions of Monoamine oxidase inhibitors?

A

Q

What are the COMT inhibitors?

A

Q

What is the inhibition of dopa decarboxylase?

A

Q

How do carbidopa, tolcapone, and entacapone interact?

A

Q

What are the COMT Inhibitors?

A

Q

What are the adverse effects of COMT INHIBITORS?

A

Q

Describe amantadine

A

Q

Describe amantadine adverse effects

A

Q

What are the useful antimuscuranics?

A

Q

Describe choice of treatment for Parkinson’s disease

A