Agents That Affect Bone Mineral Homeostasis Flashcards

1
Q

What is the PTH analogs?

A

Teriparade

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2
Q

What is the importance of calcium & phosphate?

A
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3
Q

What are bone dynamics mediated by?

A
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4
Q

What’s the importance of PTH?

A
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5
Q

What’s the importance of Vitamin D?

A
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6
Q

Describe calcitonin

A
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7
Q

Describe fibroblast Growth Factor 23 (FGF 23)

A
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8
Q

Where are estrogen receptors found?

A
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9
Q

Describe the effects of androgens

A
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10
Q

Describe glucocorticoids

A
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11
Q

Describe hypercalcemia

A
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12
Q

Describe hypocalcemia

A
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13
Q

What are the common risk factors of osteoporosis?

A
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14
Q

Describe preventative measures which reduce fracture risk

A
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15
Q

What are the bisphonates?

A
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16
Q

What are the purpose of Bisphosphonates?

A
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17
Q

What are first-generation bisphosphonates?

A
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18
Q

What are the second generation bisphonates?

A
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19
Q

What are the third generation bisphonates?

A
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20
Q

Describe the oral bioavailability of alendronate and risedronate

A
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21
Q

Contrast oral and intravenous buphosphonate

A
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22
Q

What is Zoledronate?

A
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23
Q

What is pamidronate?

A
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24
Q

What is Zoledronate

A
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25
What are biphosphonates used for?
26
What is Denosumab?
27
How is Denosamub administered?
28
What is teriparade?
29
What’s the MOA of teriparade?
30
What are the SERMs?
Raloxifene Tamoxifen
31
When are SERMs used?
32
What are the functions of Raloxifene?
33
What’s the MOA of Raloxifene ?
34
What are the adverse effects of Raloxifene?
35
What are the actions of tamoxifen?
36
What’s the purpose of tamoxifen?
37
Explain the purpose of calcitonin
38
What is osteomalacia?
39
What are the causes of osteomalacia?
40
What’s ergocalciferol & cholecalciferol?
41
What’s pagets disease?
42
What’s the goal of Paget’s disease?
43
What are the bisphonates examples?
44
What bisphonates are clinically approved for Paget’s disease?
45
What is etidronate?
46
Why is salmon derived calcitonin important?
47
What is pilcamycin?
48
What are the toxicities of pilcamycin?
49
Explain the pathology of chronic kidney disease mineral and bone disorder
50
What two phenotypes can chronic kidney disease mineral and bone disorder be divided into?
51
What is Sevelamer?
52
What are the adverse effects of Sevelamer?
53
What is the purpose of Paricalcitol and Doxercalciferol?
54
Describe Cinacalcet
55
What’s the use of Gallium nitrate?
56
How does fluoride affect osteoblast activity?
57
Where do humans obtain fluoride?
58
What are the fluoride salts employed in toothpaste?
59
What are the uses of thiazides?
60
What are the toxicities of thiazides?
61
Describe calcium supplements
62
What’s the importance of calcipotriol?
63
What are the adverse effects of calcipotriol?