Pathology Of Bones & Joints 2 Flashcards
Describe childhood and adolescence modeling
When is there peak bone mass attained, what causes it?
Describe the regulation of bone remodeling
Describe multicellular unit
What are the main intercellular bone signals?
Discuss the regulation of osteoclasts
What is osteoporosis?
What are the classifications of osteoporosis?
Describe the DEXA scan signs of osteoporosis
Discuss primary osteoporosis
What are the risk factors of senile osteoporosis?
Describe the rate of loss of bone in osteoporosis
Summarize bone mass reduction in senile osteoporosis
Summarize post-menopausal osteoporosis
Contrast senile and postmenopausal osteoporosis
What does an osteoporotic vertebral body look like?
What does trabeculae look like in osteoporosis?
What endocrine factors can cause secondary osteoporosis?
Describe neoplastic causes of secondary osteoporosis
Describe gastrointestinal causes of secondary osteoporosis
Describe the drug related causes of secondary osteoporosis
What’s the common presentation of secondary osteoporosis?
Describe radiological diagnosis of secondary osteoporosis
Describe serology of secondary osteoporosis
Describe the complications of secondary osteoporosis
What is the pathogenesis of hyperparathyroidism?
Describe the formation of cystic spaces in hyperparathyroidism
Describe the Paget’s disease (osteitis deformans)
Describe the epidemiology of Paget’s disease(osteitis deformans)
Describe the etiology & risk factors of Paget’s disease
Describe the pathogenesis of Paget’s disease (osteitis deformans)
Describe the osteolytic phase of Paget’s disease
Describe the mixed phase of Paget’s disease
Describe the blastic phase of Paget’s disease
What are the phases of Paget’s disease in order?
- Osteolytic
- Mixed phase
- Blastic phase
Describe the clinical presentation of Paget’s disease
What are the investigations of Paget’s disease?
Explain the Mosaic/jigsaw pattern of bone in Paget’s disease
What are the complications of Paget’s disease?
What are the rare complications of Paget’s disease of osteitis deformans?
What is renal osteodystrophy?
Describe the etiopathogenesis of renal osteodystrophy
What are the manifestations of renal osteodystrophy?
Describe end stage renal disease
What are the clinical features of end stage renal disease?
Describe the etiology & risk factors of Vitamin D deficiency
Describe the pathogenesis of vitamin D deficiency
Explain the histology of rickets
Describe osteomalacia
Summarize Scurvy