Anxiolytics Flashcards
What are anxiolytics?
What are hypnotics?
What are the groups of anxiolytics & hypnotics?
What drugs are used to treat depression?
What are benzodiazepines?
Where does GABA bind?
What’s the importance of a2B2y for benzodiazepines?
Where are the binding sites for GABA located?
Summarize the MOA of benzodiazepines
How do benzodiazepines enhance GABA-induced chloride influx?
What are the actions of benzodiazepines?
Describe the absorption and distribution of benzodiazepines
Describe the duration of action of benzodiazepines
What are the long-acting benzodiazepines?
What are the intermediate acting benzodiazepines?
What are the short-acting benzodiazepines?
Where do benzodiazepines go to become metabolized?
Undergo phase 1 reactions/conjugation mainly by CYP34A
What happens to the metabolites of benzodiazepines?
What happens to oxazepam, lorazepam, and temazepam?
What happens to flurazepam?
What are usually used to treat anxiety disorders?
What benzodiazepine is used to treat muscular disorders?
What benzodiazepines are made for seizures ?
What benzodiazepines are made for drug withdrawal?
What benzodiazepines are made for anesthesia?
What benzodiazepines are made for sleep disorders?
What are the adverse psychological effects of benzodiazepines?
How can benzodiazepines lead to dependence?
What’s the main use of Flumazenil as a benzodiazepine antagonist?
Describe the administration, onset and duration of flumazenil
What are barbiturates?
Describe the mechanism of action of barbiturates
Describe dose-response relationship of benzodiazepines & barbiturates
Describe GRAPHICALLY dose-response relationship of benzodiazepines & barbiturates
What are the actions of barbiturates?
What are the clinical uses of barbiturates?
What are the adverse effects of barbiturates?
What are the non-benzodiazepune benzodiazepine receptor agonists?
What are the effects of non-benzodiazepine benzodiazepine receptor agonists ?
what are the properties of zolpiidem?
What are the properties of zolpidemmER?
30 min onset
Intermediate acting
1.6-5.5 half-life
Used to treat insomnia characterized by difficulties with sleep onset and/or sleep maintenance
What are the properties of zaleplon?
20 min onset
Ultrashort acting
1hr half life
Short-term treatment of insomnia
What are the properties of Eszopiclone?
Treatment of insomnia
What is Buspirone? What is its use? What’s the MOA?
What are the uses of Buspirone?
What is Ramelteon?
What are the adverse effects of Ramelteon?
What are the orexin receptor antagonists?
What are Suvorexant & lemborexant indixated for?
Describe propranolol indications?
Describe doxepin as an anyihistaminics
Describe hydroxyzine as an antihostaminic
How do we treat OCD?
How do we treat PTSD?
How do we treat performance anxiety?
