Antiepileptics Flashcards

1
Q

What are epilepsies and seizures?

A
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2
Q

What is Used to treat epilepsy?

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3
Q

What have seizures been classified based on?

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4
Q

What are the classifications of seizures?

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5
Q

What are focal aware seizures?

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6
Q

What are focal impaired awareness seizures ?

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7
Q

What are the focal-to-bilateral tonic-clonic seizures?

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8
Q

What are generalized Tonic-clonic seizures?

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9
Q

What are absence seizures ?

A
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10
Q

What are absence seizures going to look like on EEG?

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11
Q

What are atypical absence seizures?

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12
Q

What are atonic seizures?

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13
Q

What are myoclonic seizures?

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14
Q

What’s the role of GABA in seizures?

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15
Q

What has experimental data shown us About seizures?

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16
Q

What’s the MOA of anti epileptic drugs?

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17
Q

What are the categories of drugs that block voltage gated ion channels?

A
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18
Q

What drugs are used to block voltage-gated Na+ channels?

A
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19
Q

What drugs are affected by the drugs that block voltage Na+ channels?

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20
Q

What drugs are sodium channel blockers (not used for this, but block)?

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21
Q

What drugs black T-type Ca2+ channels?

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22
Q

What categories of drugs affect synaptic transmission?

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23
Q

Where do drugs enhance GABAergic neurotransmission?

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24
Q

What drugs enhance GABAergic neurotransmission postsynaptically?

A
25
Q

What drugs enhance the GABAergic neurotransmission presynaptically?

A
26
Q

Where can drugs reduce glutamatergic neurotransmission?

A
27
Q

How do phenobarbital and toporamate work ?

A
28
Q

How do gabalin, pregabalin and leviteractam work?

A
29
Q

What are the principles of anti epileptic treatment?

A
30
Q

What are the main drugs used in focal and generalized tonic-clinic seizures?

A
31
Q

How do we treat absence seizures?

A
32
Q

How do we treat myoclonic seizures ?

A
33
Q

How do we treat atonic seizures?

A
34
Q

How do we treat epileptic encephalopathies?

A
35
Q

What are febrile convulsions? How do we treat them?

A
36
Q

What is status epilepticus?

A
37
Q

How do we manage status epilepticus?

A
38
Q

How can drug-induced seizures be treated?

A
39
Q

What drugs induce P450?(high yield)

A
40
Q

What are the adverse effects f valproate?

A
41
Q

What are the adverse effects of phenytoin?

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42
Q

What are the adverse effect of carbamazepine?

A
43
Q

What drugs are high risk for rash & Steven-Johnson syndrome?

A
44
Q

What is Stevens-Johnson syndrome?

A
45
Q

What are the adverse effects of phenobarbital?

A
46
Q

What are the adverse effects of primidone?

A
47
Q

What are the adverse effects of vigabatrin?

A
48
Q

What are the adverse effects of felbamate?

A
49
Q

How do we discontinue anti epileptic Therapy?

A
50
Q

Elaborate on overdose toxicity of anti epileptic drugs

A
51
Q

What do we have to worry about anti epileptic drugs and pregnancy?

A
52
Q

Describe teratogenicity of antiepileptics

A
53
Q

Describe newborn hemorrhagic disease

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54
Q

What are the extra uses of anti seizure drugs?

A
55
Q

What are some non Pharmological approaches ?

A
56
Q

How do antiepileptics help in surgery?

A
57
Q

What’s the dietary benefit for antiepileptics?

A
58
Q

How can vagus nerve stimulation help with antiepileptics?

A