Antifungal Drugs Flashcards

1
Q

What are the categories of fungal infections?

A
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2
Q

What are the 3 most common fungal infections?

A
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3
Q

How are fungi different from bacteria?

A
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4
Q

Why has there been an increase in fungal infections?

A
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5
Q

How can antifungal drugs be classified MOA?

A
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6
Q

Discuss the systemic drugs for subcutaneous and systemic mycoses

A
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7
Q

What type of chemical is amphotercin B?

A

Polyene antibiotic

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8
Q

What’s the MOA of Amphotercin?

A
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9
Q

Discuss the antifungals activity of amphotercin B

A
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10
Q

Discuss the PK of amphotercin B

A
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11
Q

What are the uses of amphotercin B?

A
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12
Q

What’s the infusion related toxicity of amphotercin B?

A
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13
Q

How does amphotercin B leading to renal toxicity?

A
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14
Q

How does renal toxicity present in amphotercin B?

A
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15
Q

How is the liver, kidney and blood Affected by amphotercin B?

A
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16
Q

Discuss the propensity of amphotercin B to induce seizures

A
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17
Q

Why have lipid formulations of amphotercin B been produced?

A
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18
Q

What are the lipid formulations of amphotercin B?

A
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19
Q

What is flucytosine?

A
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20
Q

Discuss the MOA of flucytosine

A
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21
Q

How can flucytosine be synergistic?

A
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22
Q

Discuss the spectrum of flu cytosine

A
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23
Q

What are the uses of flucytosine?

A
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24
Q

Discuss the adverse effects of flucytosine

25
Q

What are azoles?

26
Q

What are the MOA of azoles?

27
Q

What are the adverse effects of azoles?

28
Q

What is ketoconazole?

29
Q

What does ketoconazole inhibit?

30
Q

What are the uses of ketoconazole?

31
Q

What is a fluconazole?

32
Q

What are the uses of fluconazole?

33
Q

What is Itraconazole?

34
Q

What are the uses of itraconazole?

35
Q

What is voriconazole?

36
Q

What metabolizes and inhibits voriconazole?

37
Q

What is posaconazole?

38
Q

What is caspofungin?

39
Q

Discuss the MOA caspofungin

40
Q

Discuss the drug categories of superficial mycoses

A

Systemic and topical

41
Q

What are the systemic drugs for superficial mycoses?

42
Q

What’s Grisefulvin and it’s MOA?

43
Q

What are the uses of Grisefulvin?

44
Q

What is terabinafine?

45
Q

What’s the MOA of terbinafine?

46
Q

What are the uses of terbnafine?

47
Q

What are the adverse effects of terbanifine?

48
Q

What are the azoles used for?

49
Q

What are the total drugs for superficial mycoses?

50
Q

What is nystatin?

51
Q

Describe the toxicity of nystatin

52
Q

What is the main thing amphotercin b used for?

53
Q

What are the topical azoles

54
Q

How 8s terbinafine available?

55
Q

What’s cause of pneumocystis jirovecii?

56
Q

Why is P. jirovecii resistant to antifungals?

57
Q

How do we treat pneumocystitis jirovecii?

58
Q

what are the alternative therapies of PNP?