MNI lecture 3 Flashcards by Jhaunte Braithwaite

Q

Give some symptoms of major depression

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Q

What are the symptoms of bipolar depression?

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Q

What is the history of the monoamine hypothesis?

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Q

What is the monoamine hypothesis?

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Q

What Medications are used reinforce the monoamine hypothesis? What are the weakness of the hypothesis?

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Q

How is depression caused hby the monoamine hypothesis?

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Q

What are the general features of antidepressants drugs ?

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Q

What are MAOIs? What are there mechanism of action?

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Q

What is the mechanism of action of MAOIs?

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Q

What are the adverse effects of MAOIs?

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Q

What are the drug interactions of MAOIs?

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Q

What is serotonin syndrome?

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Q

How is serotonin syndrome managed?

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Q

What is the cheese reaction of MAOIs?

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Q

How can OTC cold preparations affect the cheese reactions? What does sympathommimmetic drugs cause when combined with a MAOI ?

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Q

How is the cheese reaction treated/managed?

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Q

What are the tricyclic antidepressants?

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Q

Describe the MOA of TCAs

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Q

What are the categories of tricyclic antidepressants adverse effects?

A

a-adrenergic receptors

Muscuranic receptors

Histamine receptors

Cardiac Na Channels

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Q

What are the tricyclic anterior at a-adrenergic receptors?

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Q

What are the tricyclic adverse effects at muscuranic receptors?

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Q

What are the tricyclic anterior at histamine receptors?

A

Sedation + weight gain

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Q

What are the tricyclic adverse effects at Cardiac Fast Na Channels?

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Q

How does an overdose in TCAs occur? What happens? Same for salicylates

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What are the SSRIs?

What is the D.O.C. for depression?

SSRIs

What is the MOA of SSRIs?

What are the adverse effects of SSRIs?

What are the drug interactions of SSRIs?

What are the consequences of an overdose of an SSRI?

What are the serotonin antagonists/reuptake inhibitors?

Describe the mechanism of action of SARIs

What are the prohibitions of Nefazodone?

Describe Trazodone

What are the SNRIs?

Describe the mechanism of action of SNRIs

Describe Venlafaxine as an SNRI

Describe duloxetine as an SNRI

Describe drug interactions of SNRIs

Describe Bupropion as an NDRI

What happens in an overdose of bupropion?

Seizures

Where does the NASSA Mitrazapine antag9nize?

What is the antidepressants discontinuation syndrome ?

What are the symptoms of antidepressants discontinuation syndrome?

Describe the incidence of antidepressants discontinuation syndrome

Contrast the amine pump block of tricyclic antidepressants

Contrast the SSRIs symptoms and amine pump block

What are the intensity and symptoms of Venlafaxine ?

What are the intensity and symptoms of Bupropion?

Contrast Trazodone & Nefazodone symptoms & intensity

Contrast Mirtazapine symptoms & intensity

What are the main adjuncts to depression?

What antidepressants are used for anxiety?

What eating disorders are treated with Antidepressants?

What antidepressants are used for chronic pain ?

What antidepressants are used for premenstrual dysphoric disorder?

Which antidepressant is used for smoking cessation?

What are the warnings & precautions of antidepressants?

What is the drug of choice for bipolar disorder? What can be used prophylactically?

What is the inositol depletion theory? How does this affect lithium?

Describe the mechanism of action of lithium

Where does lithium block phosphatidylinositol signaling cascade?

What are the adverse effects of lithium?

How can we manage the Adverse effects of lithium ?

What are the effects of lithium on pregnancy? What is its category?

What should be monitored when a patient is taking lithium?

What are the drug interactions of lithium?

What are the alternatives to lithium?