MNI lecture 3 Flashcards by Jhaunte Braithwaite | Brainscape

Q

Give some symptoms of major depression

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Q

What are the symptoms of bipolar depression?

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Q

What is the history of the monoamine hypothesis?

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Q

What is the monoamine hypothesis?

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Q

What Medications are used reinforce the monoamine hypothesis? What are the weakness of the hypothesis?

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Q

How is depression caused hby the monoamine hypothesis?

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Q

What are the general features of antidepressants drugs ?

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Q

What are MAOIs? What are there mechanism of action?

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Q

What is the mechanism of action of MAOIs?

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Q

What are the adverse effects of MAOIs?

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Q

What are the drug interactions of MAOIs?

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Q

What is serotonin syndrome?

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Q

How is serotonin syndrome managed?

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Q

What is the cheese reaction of MAOIs?

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Q

How can OTC cold preparations affect the cheese reactions? What does sympathommimmetic drugs cause when combined with a MAOI ?

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Q

How is the cheese reaction treated/managed?

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Q

What are the tricyclic antidepressants?

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Q

Describe the MOA of TCAs

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Q

What are the categories of tricyclic antidepressants adverse effects?

A

a-adrenergic receptors

Muscuranic receptors

Histamine receptors

Cardiac Na Channels

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Q

What are the tricyclic anterior at a-adrenergic receptors?

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Q

What are the tricyclic adverse effects at muscuranic receptors?

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Q

What are the tricyclic anterior at histamine receptors?

A

Sedation + weight gain

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Q

What are the tricyclic adverse effects at Cardiac Fast Na Channels?

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Q

How does an overdose in TCAs occur? What happens? Same for salicylates

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Q

What are the SSRIs?

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Q

What is the D.O.C. for depression?

A

SSRIs

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Q

What is the MOA of SSRIs?

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Q

What are the adverse effects of SSRIs?

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Q

What are the drug interactions of SSRIs?

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Q

What are the consequences of an overdose of an SSRI?

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Q

What are the serotonin antagonists/reuptake inhibitors?

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Q

Describe the mechanism of action of SARIs

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Q

What are the prohibitions of Nefazodone?

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Q

Describe Trazodone

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Q

What are the SNRIs?

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Q

Describe the mechanism of action of SNRIs

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Q

Describe Venlafaxine as an SNRI

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Q

Describe duloxetine as an SNRI

A

Q

Describe drug interactions of SNRIs

A

Q

Describe Bupropion as an NDRI

A

Q

What happens in an overdose of bupropion?

A

Seizures

Q

Where does the NASSA Mitrazapine antag9nize?

A

Q

What is the antidepressants discontinuation syndrome ?

A

Q

What are the symptoms of antidepressants discontinuation syndrome?

A

Q

Describe the incidence of antidepressants discontinuation syndrome

A

Q

Contrast the amine pump block of tricyclic antidepressants

A

Q

Contrast the SSRIs symptoms and amine pump block

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Q

What are the intensity and symptoms of Venlafaxine ?

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Q

What are the intensity and symptoms of Bupropion?

A

Q

Contrast Trazodone & Nefazodone symptoms & intensity

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Q

Contrast Mirtazapine symptoms & intensity

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Q

What are the main adjuncts to depression?

A

Q

What antidepressants are used for anxiety?

A

Q

What eating disorders are treated with Antidepressants?

A

Q

What antidepressants are used for chronic pain ?

A

Q

What antidepressants are used for premenstrual dysphoric disorder?

A

Q

Which antidepressant is used for smoking cessation?

A

Q

What are the warnings & precautions of antidepressants?

A

Q

What is the drug of choice for bipolar disorder? What can be used prophylactically?

A

Q

What is the inositol depletion theory? How does this affect lithium?

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Q

Describe the mechanism of action of lithium

A

Q

Where does lithium block phosphatidylinositol signaling cascade?

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Q

What are the adverse effects of lithium?

A

Q

How can we manage the Adverse effects of lithium ?

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Q

What are the effects of lithium on pregnancy? What is its category?

A

Q

What should be monitored when a patient is taking lithium?

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Q

What are the drug interactions of lithium?

A

Q

What are the alternatives to lithium?

A