TOGAVIRIDAE

Question 1

Genus

Answer 1

(Toga - Roman cloaks)

1. Alpha
2. Rubivirus

Question 2

Morphology

Answer 2

Enveloped

+ssRNA genome

Question 3

Resistance

Answer 3

Weak - Enveloped!

Question 4

Biological properties

Answer 4

Baltimore IV - Single precursor poly protein
No CPE, but HEAMAGGLUTINATE
Alphavirus - Zoonosis!
Arboviruses - Airborne vectors - mosquitos

Question 5

Antigenic properties

Answer 5

Good antigens

Cross reaction within Genera

Question 6

Diagnosis

Answer 6

Clinical signs, IF

Serology - ELISA, IF, HAI

Question 7

Alphavirus genome

Answer 7

(Alpha - A group of arboviruses)

1. Eastern, Western & Venisuelan EQUINE ENCHEPHALITIS - USA
   - Horse, Human : CNS symptoms
   - Bird reservoir: Mosquito transmission

• Chikungunya: Africa, Indonesia, India - “Bends you up”
• Humans;
  Muscle pain,
  Joint pain,
  Fever,
  Rash
• O Nyong Nyong
• Humans:
  Fever
  Rash

2. Horse encephalitis - Japan
   * Semliki forest virus

Question 8

Rubrivirus Genus

Answer 8

Rubeus - Red Rash

1. Rubella
   - Fever
   - Rash in children
   - Fethopathy => Blindness in foetus