BORNAVIRIDAE

Question 1

Genus

Answer 1

(Borna- Horse disease - Germany)

Bornavirus

Question 2

Morphology

Answer 2

Enveloped
-ss RNA genone
Helical capsid

Question 3

Resistance

Answer 3

Weak

Question 4

Biological properties

Answer 4

– Baltimore V
1. Host specificity? – Typically described in horses – encephalitis

2. But other species infected
   – swine, dogs, cats, humans?
   Shrews – reservoirs – contaminate grass
3. Restricted geography
   • Europe, possibly Japan

Question 5

Antigenic properties

Answer 5

Good antigens

– was a vaccine

Question 6

Diagnosis

Answer 6

• Clinical symptoms, histopathology lesions

RT-PCR

Question 7

Borna diseases (BDV)

Answer 7

1. Encephalitis 
– Horses 
– sheep, 
- cattle, 
- humans??

2. Avian Borna virus
   – High mortality