BUNYAVIRIDAE

Question 1

Genus

Answer 1

(Bunyamwera – African region)

1. Orthobunya-,
2. Phlebo-,
3. Nairo-,
4. Hantavirus

Question 2

Morphology

Answer 2

Enveloped

• ssRNA genome, Segmented (3),
• Helical capsid – RNA polymerase enzyme – synthesizes mRNA

Question 3

Resistance

Answer 3

Weak

Question 4

Biological properties

Answer 4

Baltimore V – viral transcriptase

• Zoonoses
• Arbo-viruses except Hantavirus - mosquito or tick bourne

Question 5

Antigenic properties

Answer 5

Good antigens

Cross reaction within genera

Question 6

Diagnostic

Answer 6

Isolation, IF, EM

Indirect – VN – but needs a certified lab

Question 7

Orthobunyavirus

Answer 7

1. Akabane disease
   - Ruminants- development problems of foetus
2. La Crosse virus – USA
   - Encephalitis – children

Question 8

Phlebovirus

Answer 8

(Sandflies)

• Rift valley fever – Notifiable
  
  • Ruminants – abortion, fever, diarrhea
  • Causes economic issues

Question 9

Nairovirus

Answer 9

(Nairobi)

1. Nairobi sheep fever
   – Sheep, goats – fever, abortion
2. Crimean-congo haemorrhagic fever
   – Esp Human – Haemorrhage, rash,– Turkey, Iraq

Question 10

Hantavirus

Answer 10

(Korea)

1. Haatan Haemorrhagic Fever 
   – with renal syndrome
- Kidney damage
– necrosis 
– highly lethal

• Resevoir – rats
  6-8 cases in Hungary/year