PAPILLOMAVIRIDAE Flashcards
1
Q
General
A
Family-Papillomaviridae-
One Genus=Papilloma Virus
papilla-wart, oma-tumour
2
Q
Morphology
A
Non-enveloped
Icosahedral capsid
dsDNA-(Circular)
Superhelical; ~ 55 nm
3
Q
Resistance
A
Strong
With strands
(56°C, 30 min; pH 3, lipid solvents)
4
Q
Replication
A
In the nucleus by cellular transcriptase
5
Q
Biological properties
A
- Propagate in keratinized cells (skin cells)
- Stenoxenous
- Oncogenic
- Latent
- Can hide easily from the immune system
- Transmitted by: contact/sex
6
Q
Antigenic properties
A
Good
7
Q
Diagnosis
A
Clinical signs
IF
EM
NA hybridisation
8
Q
Papylomavirus genus
A
- Equine papilomatosis - Head, nose
- Bovine papilomatosis - neck, head, back
- Horse sarcoid - tumours around eye
- Canine oral papilomatosis - oral mucosa
Human:
- Skin papilomas - verruca vulgaris
- Genital papilomas - STD
- Cervical cancer (16 and 18)
9
Q
Warts=
A
Papillomas:
Benignant tumors – pre-malignant status
