PARAMYXOVIRIDAE Flashcards
1
Q
Subfamily
A
Paramyxoviridae (para – like, myxa – mucous) - Similar to Orthomyxoviridae
- Respiro-,
- Morbilli-,
- Avula -
- Pneumovirinae
4a. . Peneumo - b. Metapneumo -
2
Q
Morphology
A
Enveloped
-ssRNA
Helical capsid
3
Q
Resistance
A
Weak
4
Q
Biological properties
A
1- Baltimore V
– viral transcriptase Proteins
2- Surface
– HN and NA again
3- F protein
– fuses cell membrane to viral envelope
4- CPE – Inclusion bodies,
5- Syncytia (Giant Cells),
6- Hemadsorption
A.) Respiro-, Rubula- - Euryxen
– infect several hosts
B.) Morbillivirus, Pneumovirinae
– infect one host
5
Q
Antigenic properties
A
Good antigens
– recognized by immune system
– vaccines available
Some cross reactions with Genera
– esp to Morbillovirus
6
Q
Diagnosis
A
Easy to isolate
– infect different cell types and show different CPE
HA, IF Indirect –
serology – VN, HAI
7
Q
Respirovirus
A
(Respiratory disease)
- Parainfluenza virus 1 –
Humans – influenza like symptoms - Parainfluenza virus 3 -
Cattle, sheep – shipping fever
8
Q
Morbillivirus
A
(Morbilli – measles)
- Canine Distemper virus
- Dogs and other carnivores
–not cats:Fever and respiratory symptoms
- Chronic encephalitis of CNS - Rinderpest -
Cattle – high economic loss
Fever, hemorrhage - Measles -
- Human – fever, rash
9
Q
Rubula-virus
A
- Parainfluenza Virus 2
- Dog – Kennel cough (with CAV-2)
- Human – influenza type virus - Parainfluenza Virus 4
- Humans - Mumps -
Humans
– salivary gland swelling
-Adults testicles, breasts – mastitis
10
Q
Avula-virus
A
1– Avian Newcastle disease
(Avian paramyxovirus 1)
- Euryxen – birds + zoonosis - Several strains
- Avian paramyxovirus 2-9
11
Q
Pneumovirinae –
A
- Pneumovirus
– Bovine/Ovine/Human respiratory syncytial virus (RS)
- Severe pneumonia, emphysema - Metapneumovirus
– Turkey rhinotracheitis Virus (TRT)
Swollen Head Synsdrome (SHS) - Chickens
