PICORNAVIRIDAE

Question 1

Genus

Answer 1

(pico-RNA)

1. Enterovirus
2. Teschovirus
3. Rhinovirus
4. Hepatovirus
5. Cardiovirus
6. Apthovirus
7. Erbovirus

Question 2

Morphology

Answer 2

+ssRNA genome

Non enveloped

Question 3

Resistance

Answer 3

Generally good - esp

• Entero
• Hepato
• Tescho -56*

Question 4

Biological properties

Answer 4

• Baltimore IV
• A single poly protein, processed by viral enzymes
• Generally stenoxen -> Host specific
  (exept: Aphto - F&M disease)
• CPE - Cell rounding

Question 5

Antigenic properties

Answer 5

Good antigens

No cross reaction with other viruses

Question 6

Diagnosis

Answer 6

1. Isolation
2. IF or CF (component fixation)
3. Indirect:
   - VN
   - CF
   - AGID
   - ELISA

Question 7

Enterovirus

Answer 7

INTESTINE

• SVD - Swine vesicular disease
• swine: very similar clinically sign as Foot&Mouth disease symptoms.
• Antigenic structure: Similar to Human Coxakie B5 virus
• Human poliovirus- Polioencepamyelitis
• Human coxakie A&B virus - Aceptic meninges within CNS
• Human echovirus
• Enteric Cytoplasmic Human Orphan

Question 8

Teschovirus

Answer 8

TESCHEN in Czech

• Teschen/Taffan disease
• Porcine Teschovirus 1
• Affects spinal chord - Paralysis

Question 9

Rhinovirus

Answer 9

RHINOS = Nose

• “Common cold”
• cattle 1-3, humans >100
• Thermosensitive -33* - hence in nose =lower

Question 10

Hepatovirus

Answer 10

HEPATOS = Liver

• Hepatitis A
• Via oral route (drinking etc)
  = Jaundice
• Avian encephalomyelitis
• Chicken
• Tremors

Question 11

Cardiovirus

Answer 11

CARDIO - Heart

• Encephalomyocarditis
• Euryxen (infects several species)
• Swine, Horse, Humans

Question 12

Aphthovirus

Answer 12

APTHA - Vesicle

1. Foot & Mouth disease

• Serotypes:
  
  • O
  • A
  • C
  • SAT1-4 (S. african teritories)
• Euryxen:
  
  • Effects other hosts:
    
    • Ruminants
    • Swine (humans)
• Clinical signs:
  
  • In vesicles
  • Oral cavity
  • Hoofs
  • Myocarditis

2. Equine Rhinitis A
3. Equine Rhinitis B

Question 13

The Picorna Order

Answer 13

A proposed new order
= Virus with similar morphology

1. Criptavirus
   * Aparavius - Acute bee paralysis / Israeli Kashmire bee virus
2. Ifravirus
   * Sacbrood virus
   * Deformed wing virus