RHABDOVIRIDAE

Question 1

Genus

Answer 1

Rhabdos – rod, stick – plant virus)

1. Vesiculo-,
2. Lyssa-,
3. Ephermero - ,
4. Novirhabdo-virus

Question 2

Morphology

Answer 2

• Enveloped
  -ssRNA genome
• Helical capsid
• Complete virions
  – bullet shaped (B) or Truncated (T)

Question 3

Resistance

Answer 3

Weak

Question 4

Biological properties

Answer 4

1. Baltimore V
2. Viral transcriptase
   – NA cannot be read
3. Cell bound infections (as weak resistance)
   - CPE
   – weak – IF needed
4. Fish vesiculovirus
   – thermosensitive, 23⁰C
5. Zoonoses

Question 5

Antigenic properties

Answer 5

Good
- Cross reactions within Genera
– Vaccines – (eg Rabies)

Question 6

Diagnosis

Answer 6

IF, isolation + IF

Experimental infection + IF

Question 7

Vesiculovirus

Answer 7

1. Vesicular stomatitis virus
   - Ungulates, humans – America
   - Similar to Foot & Mouth, but Infects horses – FMD does not

Question 8

Lyssavirus

Answer 8

(Lyssa – Rabies)

1. Rabies - Serotypes –Lagos Bat, European Bat etc
   - Neuroinvasive -> behavior change (CNS)
   - Neuron encephalitis
2. Urban rabies –
   - dogs 
   - humans (30k die/year)
   - Post exposure vaccination
3. Sylvatic rabies – (forest) fox, wolf, raccoon, bat
   - Foxes vaccinated in wild
   - Largely eradicated

Question 9

Ephemerovirus

Answer 9

1. Bovine ephemeral fever - Short fever

- Less milk production

Question 10

Novirhabdovirus

Answer 10

Viral haemorrhagic septicemia

- Salmon in Europe