FILIOVIRIDAE Flashcards
1
Q
Genus
A
(Filum – thread)
- Ebola-,
- Marburg-virus
- Reston?
2
Q
Morphology
A
Envelope
-ssRNA genome
Helical capsid
3
Q
Resistance
A
Weak
4
Q
Biological properties
A
- Baltimore V
- viral transcriptase
- CPE – inclusion bodies
- Zoonoses – reservoir – Bats?
– mainly in Africa – Ebola!
5
Q
Antigenic properties
A
Good antigens
– but rapid course of lethal disease
– too late!
No cross reactions
6
Q
Diagnosis
A
Clinical signs –can be confused with Malaria
Isolation – EM, IF
7
Q
Ebola virus
A
(Ebola – African river)
- Ebola virus
- Bats infect fruit, apes eat fruit bush meat
- Human to human infection fast
- Severe haemorrhages + encephalitis
- Outbreaks – occasionally
- High mortality – 90%
8
Q
Marburg virus
A
(German city)
- Marburg virus
– Monkey – > Humans - African disease prim.
- Fever, meningocephalitis
- High mortality
9
Q
Reston virus
A
USA – Orphan virus?
