ARENVIRIDAE

Question 1

Genus: Arenviridae

Answer 1

(arena – sand)

Question 2

Morphology

Answer 2

• Enveloped – as all pleomorphic viruses are

–ssRNA genome. Segmented (2)

• Have ribosomes inside!
  = no function but the “sand” seen in microscope
• No capsid – “Pleomorphic”
• “Bud” through the cytoplasmic membrane
• 2 ends of NA hybridize together
• 2 key proteins on surface

Question 3

Resistance

Answer 3

Weak - enveloped

Question 4

Biological properties

Answer 4

• Baltimore V – need viral transcriptase

- Zoonoses! – only minor veterinary importance

Question 5

Antigenic properties

Answer 5

Cross reactions within genus

– Old world- and New world strains

Question 6

Diagnosis

Answer 6

Isolation, IF

Serology – VN, IF – needs certified lab

Question 7

Arenavirus

Answer 7

• Old world arena virus
  1. Lymphocytic choriomeninigitis (LCM) – inflames Lymphocytes

2. Human meningitis  paralysis
   - Pet hamsters, mice  children
3. Lassa fever – Africa
   - Severe haemorrhages