CIRCOVIRIDAE

Question 1

Genera

Answer 1

3 genus
(Circus = Circle)
1. Circovirus
2. Gyrovirus
3. Anellovirus

Question 2

Morphology

Answer 2

Non-enveloped
Icosahedral Capsid
ssDNA (circular)

Question 3

Resistance

Answer 3

Very strong
Stable in the environment
Withstands:
- Heat: 60°C for 60mins
- Acid: PH=3

Question 4

Replicate

Answer 4

• Baltimore II

- Replicates with cellular polymerase in dividing cells
Bone marrow, leukocytes

Question 5

Biological properties

Answer 5

• Stenoxenous

- Germinative infections, (esp birds)

Question 6

Antigenic properties

Answer 6

Good antigens + immune supression

Question 7

Diagnosis

Answer 7

1. Isolation of dividing cells
2. IF- Immuno-flourescence technique
3. ELISA (serology)

Question 8

Circovirus

Answer 8

MAINLY birds - goose

1. Porcine circovirus:
   - Weaning,
   - hemorrhage,
   - immunosuppression

• PMWS
• Post weaning multi systematic wasting syndrome
• PDNS
• Porcine Dermatitis + Nephrology syndrome

2. Beak and feather disease virus:
   - deformities and
   - immune suppression
3. Goose circovirus:
   - immunosuppression
4. Canary, Pidgeon, Malard duck and Muskovy duck circoviruses

Question 9

Gyrovirus

Answer 9

Chicken infectious anemia:

• Anemia and
• immunosuppression

Question 10

Anellovirus

Answer 10

1. Sentinel virus (SEN): (human circovirus)
   * It’s an orphan virus
   = (Infectious but not pathogenic)
2. Torque teno virus (TT): Human circovirus - - causes liver damage and
   - very widespread.