CORONAVIRIDAE

Question 1

Genus

Answer 1

From the Nidovirales order - Nido:Nest
(Corona - Solar crown)

1. Alphacorona
2. Betavorona
3. Gammacorona
4. Torovirus

Question 2

Morphology

Answer 2

Enveloped

+ssRNA genome - especially long

Question 3

Recistance

Answer 3

• Good (despite enveloped)

- PH resistance 3-9

Question 4

Biological properties

Answer 4

• Unique expression of genetic material
• Common for whole ORDER.
• Baltimore IV - Subgenomic mRNA
• Host specific
• CPE - cell rounding, not characteristics
• HA - Hemagglutinating activity - in some cases

Question 5

Antigenic properties

Answer 5

• Good antigens
• BUT: Immune response can increase aspects of disease
• Cross reactions w/i genera - depend on:
  
  • Sera group: ELISA, IF (crossreactions)

Question 6

Diagnosis

Answer 6

Difficult to Isolate
No CPE
- IF investigation also needed
Clinical signs: IF, IEM
Indirect: ELISA, IF (cross reactions)

Question 7

Alpha corona virus

Answer 7

1. Porcine transmissible gastroenteritis virus (TGE) – esp piglets
2. Porcine epidemic diarrhea virus (ED)
3. Feline infectious peritonitis virus (FIP)
   
   • 2 forms – Wet and dry
4. Canine coronavirus –
5. Human coronavirus –

Question 8

Beta corona virus

Answer 8

1. Bovine coronavirus: “Winter dysentery”
2. Porcine hemagluttinating encephalomyelitis virus (HEV)
3. Severe acute respiratory syndrome – SARS
   - Human pneumonia – destroys type II cells of lung

Question 9

Gammacoronaria

Answer 9

1. Avian infectious bronchitis – (IB)
   - Chickens
   – can damage oviduct also
   - egg production hindered

Question 10

Torovirus

Answer 10

1. Berne virus – Foal gastroenteritis

2. Breda virus – Calf gastroenteritis