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Pharm > Things I don't know, test 2 > Flashcards

Things I don't know, test 2 Flashcards

1
Q

Filgrastim is given with what CA drug to reduce myelosuppression?

A

Pacltaxel

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2
Q

What is the mechanism by which cell acquire resistance to cyclophosphamide?

A

Increase glutathione
Increase DNA repair
Increase MGMT enzyme to remove alkyl groups

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3
Q

What is the mechanism by which cell acquire resistance to cetuximab?

A

RAS pathway mutation

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4
Q

What is the cancer that cytarabine is used to treat?

A

AML

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5
Q

What is the cancer that fludarabine is used to treat?

A

CLL

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6
Q

What is the cancer that temsirolimus is used to treat?

A

Renal cell CA

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7
Q

What is the cancer that bortezomib is used to treat?

A

Multiple myeloma

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8
Q

What is the MOA of argatroban?

A

direct thrombin inhibitor

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9
Q

What is the MOA of apixaban?

A

factor X inhibitor

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10
Q

What is the MOA of bivalirudin?

A

Bivalent thrombin inhibitor

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11
Q

What is the MOA of dabigatran?

A

Direct thrombin inhibitor

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12
Q

What is the MOA of lepirudin?

A

Bivalent thrombin inhibitor

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13
Q

What is the MOA of fondaparinux?

A

Synthetic heparin that can only inhibit thrombin

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14
Q

What is the MOA of vorapaxar?

A

PPARalpha inhibitor on platelets

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15
Q

What is the MOA of prasugrel?

A

Irreversible P2Y12 inhibitor on platelets

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16
Q

What is the MOA of clopidogrel?

A

Irreversible P2Y12 inhibitor on platelets

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17
Q

What is the MOA of ticagrelor?

A

Reversible P2Y12 inhibitor (given in active form)

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18
Q

What is the MOA of cangrelor?

A

Reversible P2Y12 inhibitor (given IV)

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19
Q

What are the specific drugs that inhibit warfarin?

A

Rifampin

Barbiturates

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20
Q

What are the two drugs that inhibit tPA?

A

Aminocaproic acid

Tranexamic acid

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21
Q

What is the cause of primary chylomicronemia?

A

Decreased LPL activity

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22
Q

What is the cause of familial hypertriglyceridemia?

A

impaired VLDL removal

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23
Q

What is the cause of familial combined hyperlipoproteinemia?

A

Increased VLDL production

24
Q

What is the cause of Familial dysbetalipoproteinemia?

A

Decreased clearance of VLDL, IDL, and chylomicrons

25
Q

What is the cause of familial hypercholesterolemia?

A

LDL receptor impairments

26
Q

What is the cause of familial ligand-defective apoB?

A

Mutation in apoB100, impaired LDL uptake

27
Q

What are the diseases that nitrates are useful for treating?

A

All hypercholesterolemia and triglyceridemia

28
Q

What is the MOA of fondaparinux?

A

Synthetic heparin that binds to antithrombin and increases the rate of factor X inhibition

29
Q

What is the MOA of Lepirudin?

A

DTI (binds to fibrin binding site, and active site)

30
Q

What is the MOA of bivalirudin?

A

DTI (binds to fibrin binding site, and active site)

31
Q

What is the MOA of argatroban?

A

DTI (binds to fibrin binding site, and active site)

32
Q

What is the MOA of dabigatran?

A

DTI (binds to fibrin binding site, and active site)

33
Q

What is the MOA of apixaban?

A

factor X inhibitor

34
Q

What is the MOA of rivaroxaban?

A

Factor X inhibitor

35
Q

What are the two drugs that inhibit tPA?

A

Aminocaproic acid

Tranexamic acid

36
Q

What is the MOA of furosemide?

A

Loop diuretic

37
Q

What is the MOA of bumetanide?

A

Loop diuretic

38
Q

What is the MOA of Ethacrynic acid?

A

Loop diuretic

39
Q

What is the first line drug for HTN with DM? Add-on therapy?

A

ACEI or ARB

Thiazide, then Beta blocker or CCB

40
Q

What is the first line drug for HTN with CKD?

A

ACEI or ARB

41
Q

What is the first line drug for HTN with CAD? Add-on therapy?

A

beta blocker with ACEI/ARB

Aldosterone antagonist, CCB, or thiazide

42
Q

What is the first line drug for HTN with LVD? Add-on therapy?

A

Diuretic + ACEI/ARB + beta blocker

Aldosterone antatongist or thiazide

43
Q

What is the first line drug for HTN with previous ischemic stroke?

A

ACEI wwo thiazide

44
Q

What is the MOA of furosemide?

A

Loop diuretic

45
Q

What is the MOA of butanide?

A

Loop diuretic

46
Q

What is the MOA of amiloride?

A

Renal epithelial Na channel inhibitor

47
Q

What is the MOA of acetazolamide?

A

CA inhibitor

48
Q

What is the MOA of metolazone?

A

Thiazide diuretic

49
Q

What is the MOA of indapamide?

A

thiazide diuretic

50
Q

What is the MA of triamterene?

A

Renal epithelial Na channel inhibitor

51
Q

How do you treat decreased LPL function? (Chylomicronemia)

A

Fibrates and niacin

52
Q

How do you treat decrease apoE function?

A

Fibrates and niacin

53
Q

How do you treat decrease apo CII function/expression? (dys

A

Fibrates and niacin

54
Q

How do you treat LDL receptor function? (familial hypercholesterolemia)

A

Statins
Ezetimibe
Resins
Niacin

55
Q

How do you treat decrease apo B100? (familial dysbetalipoproteinemia)

A

Statins
Ezetimibe
Resins
Niacin

Pharm (73 decks)

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