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Pharm > Cardio XI > Flashcards

Cardio XI Flashcards

1
Q

What is the cause of the proarrhythmic effect of digoxin?

A

Lower K concentration within myocytes

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2
Q

What lab values must be kept an eye on with dig?

A

K

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3
Q

What is the half life of digoxin?

A

36-48 hours

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4
Q

How long does it take to achieve steady state [digoxin]?

A

7 days

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5
Q

What organ is responsible for digoxin clearance?

A

Kidneys

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6
Q

What disease can affect the digoxin dosing?

A

CKD

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7
Q

What is the bacteria that inactivated digoxin?

A

Eubacterium lentum

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8
Q

What is the margin of safety for digoxin?

A

only 5- 10 times minimal effective dose

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9
Q

What are the two major adverse effect with digoxin?

A

Hypokalemia and arrhythmias

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10
Q

What are the first three symptoms that come about with digoxin overdose?

A

Anorexia
N/v
neuro disturbances

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11
Q

What is the major use of digoxin?

A

CHF with AF with RVR

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12
Q

Does digoxin improve QOL? All cause mortality? Hospitalization rates?

A

Improves everything, but does NOT improve all cause mortality

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13
Q

What are the two drugs to administer to pts with digoxin overdose?

A

cholestyramine

digoxin immune Fab (des IgG) digibind

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14
Q

What is the MOA of cholestyramine in digoxin intoxication?

A

Impairs absorption

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15
Q

What is the MOA of inamrinone?

A

Phosphodiesterase 3 inhibitors

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16
Q

What is the MOA of milrinone?

A

Phosphodiesterase 3 inhibitors

17
Q

What is the MOA of phosphodiesterase inhibitors?

A

Inhibits the degradation of type II phosphodiesterase, which degrades cAMP, maintaining a high Ca level in the cell in response to beta activation

18
Q

What is the MOA of viagra?

A

Blocks phosphodiesterase 5 (that degrades cAMP)

19
Q

What is the overall effect of phosphodiesterase inhibitors?

A

Same as beta blockers

20
Q

When are phosphodiesterase inhibitors indicated?

A

Short term support in advanced CHF

21
Q

What are the three goals that all drugs used in HF aim to achieve?

A
  • Decrease mortality
  • Increase exercise tolerance
  • Increase QOL

Pharm (73 decks)

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