Pharmacokinetics Flashcards
What does enteral administration mean?
Using the GI tract (oral, sublingual, buccal, rectal)
What does parenteral mean?
Non-GI delivery
IV, IM, SQ, intrathecal, epidural
What route of administration get the greatest level of compliance?
Enteral
What is the problem with using the GI tract for administering drugs?
Digests the drugs
What is buccal administration? What is the advantage of using this route, as compared to other enteral routes?
Placing drug between tongue and cheek
Bypasses the liver
What are the two major disadvantage of parenteral administration of a drug?
Pierce the skin, lowers compliance
No way to reclaim drug
Which route of administration gives the highest bioavailability?
Parenteral (IV)
What is the general type of chemical that is absorbed across the buccal mucosa?
Lipid soluble
What percent of a drug that is given rectally bypasses the liver?
~50%
What can significantly impact the absorption of a drug administered IM?
Exercise/fat distribution
What is the specific advantage of SQ administration of a drug?
Constant rate of absorption over a long period of time
What is intrathecal administration of a drug?
Injection into the subarachnoid space
What is transdermal administration?
Think patches
Lipophilic, or hydrophilic drugs are more likely to be successful with paradermal route of administration
Lipophilic
What type of drug side effects should cause concern for giving them via inhalation?
Anything that upsets the heart