Thiazide and Thiazide-Like Diuretics Flashcards
1
Q
Thiazide and Thiazide-Like Diuretics
Drug Name
A
Thiazide: Hydrochlorothiazide, Chlorothiazide
Thiazide-Like: Chlorthalidone
2
Q
Indications
A
Treatment of edema associated with CHF, liver, or renal disease.
Monotherapy or adjuncts for the treatment of hypertension.
3
Q
Mechanism of Action
A
Action is to block the chloride pump
Keeps chloride and sodium in the tubule to be excreted in the urine, thus preventing the reabsorption of both in the vascular system.
4
Q
Contraindications
A
Allergy to thiazide or sulfonamides
Fluid & electrolyte imbalances
Renal disease
Lactation
5
Q
Adverse Effects
A
GI upset Fluid and electrolyte imbalances Hypotension Hyperglycemia CNS effects: tingling, drowsiness, numbness, confusion Alkalinized urine
6
Q
Drug-Drug Interactions
A
Cholestyramine
Digoxin
Antidiabetic agents
Lithium
