Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors Flashcards
1
Q
PCSK9
Drug Names
A
Alirocumab
Evolocumab
2
Q
Indications
A
Treatment of high cholesterol levels with statin therapy or if statins are not tolerated or contraindicated
3
Q
Mechanism of Action
A
Monoclonal antibodies that bind to free PCSK9 enzyme inhibiting it from attaching to the LDL receptors on the liver cell allowing for the liver to process more LDL which decreases circulating LDL levels
4
Q
Contraindications
A
HX of serious hypersensitivity reactions
5
Q
Adverse Effects
A
Risk of infection
Injection site reactions
Allergic reaction
6
Q
Assessment
A
HX: Allergy, pregnancy/lactation
Physical: Baseline; vital signs and lung sounds
Labs: cholesterol, lipids, liver function tests
