Immune Suppressants Flashcards
Immune Suppressants Sub-Categories
Immune modulators
T and B cell suppressors
Interleukin receptor antagonists
Monoclonal antibodies
Immune Modulators:
Drug Name
Apremilast
Immune Modulators: Action
Inhibit the secretion of proinflammatory cytokines and increase the secretion of the anti-inflammatory cytokines from monocytes and have varying effects on cell proliferation
Immune Modulators: Contraindications
Pregnancy/lactation
Severe liver impairment
Immune Modulators: Adverse Effects
Unknown
Immune Modulators: Drug-Drug Interactions
Unknown
T and B-Cell Suppressors:
Drug Names
Cyclosporine Azathioprine Glatiramer Mycophenolate Tacrolimus
Cyclosporine
Suppression of rejection in variety of transplants; rheumatoid arthritis, psoriasis
Azathioprine
Prevention of rejection in renal hemotransplants; treatment of rheumatoid arthritis
Glatiramer
Reduction of number of relapses in multiple sclerosis in adults
Mycophenolate
Prevention of rejection after renal or heart transplants in adults
Tacrolimus
Prevention of rejection after heart or liver transplant
T and B-Cell Suppressors
Actions
Block antibody production by B cells, inhibit suppressor and helper T cells, and modify the release if interleukins and of T cell growth factor
T an B-Cell Suppressors
Contraindications
Known allergy, pregnancy/lactation, hepatic disease
T an B-Cell Suppressors
Adverse Effects
Increased risk for infection and for the development of neoplasms due to their blocking effect on the immune system as well as hepatotoxicity, renal toxicity, renal dysfunction, and pulmonary edema
