ACE Inhibitors

Question 1

ACE Inhibitors

Drug Names

Answer 1

Benazepril
Captopril
Enalapril
Lisinopril
Ramipril

Question 2

Indications

Answer 2

Treatment of HTN, CHF, diabetic nephropathy, left ventricular dysfunction following an MI

Question 3

Mechanism of Action

Answer 3

Blocks ACE from converting angiotensin I to angiotensin II, leading to a decrease in blood pressure, a decrease in aldosterone production, and a small increase in serum potassium levels along with sodium and fluid loss

Question 4

Contraindications

Answer 4

Allergies
Impaired renal function
Pregnancy/lactation

Question 5

Adverse Effects

Answer 5

r/t effects of vasodilation and alterations in blood flow
GI irritation
Renal insufficiency
Cough

Question 6

Drug-Drug Interactions

Answer 6

Allopurinol

Question 7

Assessment

Answer 7

HX: allergy, pregnancy/lactation
Impaired kidney function, salt/volume depletion, heart failure
Physical: Baseline; lung sounds, bowel sounds, weight, skin, vitals, and ECG
Labs: CBC and electrolytes