Acetaminophen

Question 1

Actions

Answer 1

Acts directly on the thermoregulatory cells of the hypothalamus
Mechanism of action unknown but related to analgesic effects
Used to treat pain and fever: treat pain and fever associated with a variety of conditions, including influenza; prophylaxis of children receiving diphtheria-pertussis-tetanus (DPT) immunizations; relief of musculoskeletal pain associated with arthritis

Question 2

Contraindications

Answer 2

Known allergy
Use with caution in pregnancy/lactation
Hepatic dysfunction or chronic alcoholism

Question 3

Adverse Effects

Answer 3

HA, hemolytic anemia, renal dysfunction, skin rash and fever

Hepatotoxicity usually associated with chronic use and overdose

Question 4

Drug-Drug Interaction

Answer 4

Oral anticoagulants increase bleeding

Hepatotoxicity with barbiturates, carbamazepine, hydantoins, or rifampin