Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Question 1

NSAIDs Sub-Categories

Answer 1

Propionic Acids
Acetic Acids
Osicam Derivatives
Cyclooxygenase-2 Inhibitors

Question 2

Propionic Acids

Answer 2

Ibuprofen

Naproxen

Question 3

Acetic Acids

Answer 3

Indomethacin

Ketolorac

Question 4

Osicam Derivatives

Answer 4

Meloxicam

Question 5

Cyclooxygenase-2 Inhibitors

Answer 5

Celecoxib

Question 6

Actions

Answer 6

Provide strong anti-inflammatory and analgesic effects
Sold over the counter, which may lead to abuse
Antiinflammatory, analgesic, and antipyretic effects

Question 7

Therapeutic Actions and Indications

Answer 7

Block two enzymes, known as COX-1 and COX-2

Question 8

Contraindications

Answer 8

Allergy to ant NSAIDs or salicylate, and celecoxib is also contraindicated in the presence of allergy to sulfonamides; CV dysfunction or hypertension, peptic ulcer, GI bleeding, pregnancy/lactation

Question 9

Adverse Effects

Answer 9

Nausea, dyspepsia, GI pain, constipation, diarrhea, or flatulence caused by direct GI effects of the drug.
GI bleed, dizziness, somnolence, platelet inhibition, hypertension, and even bone marrow depression

Question 10

Drug-Drug Interactions

Answer 10

Decresed diuretic effect when these drugs are taken with loop diuretics; there is potential for decreased antihypertensive effect of beta-blockers if these drugs are combined; and there have been reports of lithium toxicity, especially when combined with ibuprofen