Potassium-Sparing Diuretics

Question 1

Potassium-Sparing Diuretics

Drug Names

Answer 1

Spironolactone

Triamterene

Question 2

Indications

Answer 2

Adjuncts with thiazides or loop diuretics
For those who need a diuretic but are at risk for hypokalemia
Hyperaldosteronism

Question 3

Mechanism of Action

Answer 3

Loss of sodium with the retention of potassium

Question 4

Contraindications

Answer 4

Allergy
Hyperkalemia
Renal disease/anuria

Question 5

Adverse Effects

Answer 5

Hyperkalemia: lethargy, confusion, ataxia, muscle cramps, cardiac arrhythmias
Androgen effects: hirsutism, gynecomastia, deepening of the voice, irregular menses

Question 6

Drug-Drug Interaction

Answer 6

Salicylates