Direct-Acting Cholinergic Agonists Flashcards

1
Q

Direct-Acting Cholinergic Agonists

Drug Names

A

Bethanechol
Carbachol
Cevimeline
Pilocarpine

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2
Q

Indications

A

Urinary retention
Induce miosis
Treat dry mouth

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3
Q

Mechanism of Action

A

Acts at cholinergic receptors in the peripheral nervous system to mimic the effects of ACh and parasympathetic stimulation

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4
Q

Contraindications

A

Any condition that would be exacerbated by parasympathetic effects-bradycardia, hypotension
Known allergy, peptic ulcer disease
Intestinal obstruction or recent GI surgery
Asthma
Bladder obstruction
Epilepsy and parkinsonism

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5
Q

Adverse Effects

A

Nausea, vomiting, cramps, diarrhea, increase salivation, and involuntary defecation
Bradycardia, heart block, hypotension
Urinary urgency
Flushing or increased sweating

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6
Q

Drug-Drug Interactions

A

Acetylcholinesterase

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7
Q

Assessment

A

HX & Physical Exam: known allergy, bradycardia, vasomotor instability, peptic ulcer, and obstructive urinary or GI diseases; recent GI or genitourinary surgery; asthma; parkinsonism or epilepsy; vital signs, lung sounds, cardiac status, bowel sounds, and I&O

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