Class IV Antiarrhythmic Drugs

Question 1

Class IV Antiarrhythmic Drugs

Drug Names

Answer 1

Diltiazem

Verapamil

Question 2

Indications

Answer 2

Supraventricular tachycardia (SVT)
Control the ventricular response to rapid atrial rates

Question 3

Mechanism of Action

Answer 3

Block the movement of calcium ions across the cell membrane, depressing the generation of action potentials and delaying phases 1 and 2 repolarization, which slows automaticity and conduction

Question 4

Contraindications

Answer 4

Idiopathic hypertrophic subaortic stenosis, renal and liver impairment

Question 5

Adverse Effects

Answer 5

Dizziness, weakness, fatigue, depression, GI upset, hypotension, CHF, and shock