T cell RECEPTOR COMPLEX HELPERS

Question 1

signal transduction unit for the TCR

Answer 1

CD3

Question 2

aka CTLA-4 for binding to B7 protein on the APC to deliver a co stimulation or an inhibitory signal to the cell; no binding here means you will not get a response

Answer 2

CD28

Question 3

aka CD154 for binding to CD40 on dendritic cells, macrophages, and B cells to promote their activation

Answer 3

CD40L

Question 4

initiates apoptosis in a target cell that express FAS on its surface

Answer 4

FasL

Question 5

leukocyte function associated antigen 1, interacting with intercellular adhesion molecules (ICAM-1) on the target cell

the binding to ICAM-1 causes the interaction between the T cell and target cell to tighten

Answer 5

LFA-1

Question 6

this one binds to PD-L1 and inhibitory processes

Answer 6

PD-1

Question 7

cytotoxic T lymphocyte associated protein

Answer 7

CTLA-4