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KSUCPM MEDMICRO > MODULE III PART II > Flashcards

MODULE III PART II Flashcards

1
Q

what is the makeup of the class I molecule?

A

A1, A2, A3, B2

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2
Q

what is the makeup of the class II molecule?

A

A1, A2, B1, B2

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3
Q

what is MHC Class I involved in?

A

regulation of the antiviral immune responses

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4
Q

what is the MHC Class II involved in?

A

regulation of the cells of the immune system

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5
Q

T/F, RBCs can not support virus replication? what can leverage this?

A

T

Plasmodium species

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6
Q

MHC class I uses what proteins? MHC class II?

A

TAP

CLIP

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7
Q

what cells are involved in interaction with the APCs?

A

B cell lymphocytes

T cell lymphocytes

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8
Q

what are the CD4 T cell lymphocytes?

A

Th1, Th2, Th17

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9
Q

what are the CD8 T cell lymphocytes?

A

Tc, Treg

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10
Q

in T cell maturation and selection, what is this?

the T cells must recognize an MHC molecule in order to survive

A

positive selection

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11
Q

in T cell maturation and selection, what is this?

no recognition of MHC+peptide

A

failure of positive selection

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12
Q

in T cell maturation and selection, what is this?

T cells who strongly recognize, MHC molecules undergo apoptosis and eliminates self protein reacting T cells?

A

negative selection

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13
Q

where does T cell maturation and selection occur?

A

thymus

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14
Q

name this T cell?

gamma/delta TCR reactive to microbial metabolites

local responses: resident in blood and tissue

quicker responses

produce interferon gamma

A

gamma/delta T cells

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15
Q

name this T cell?

alpha/beta TCR reactive with peptides on MHC II on APCs

cytokines activate and direct immune response (TH1, TH2, TH17)

cytotoxic through Fas-Fas ligand interactions

A

CD4

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16
Q

name this T cell?

control and limit expansion of immune response; promote tolerance and memory cell development

A

CD4 CD25 Treg cells

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17
Q

name this T cell?

alpha/beta TCR reactive with peptides presented on MHC I

cytotoxic through perforin and granzymes and Fas-Fas ligand induction of apoptosis

A

CD8

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18
Q

name this T cell?

alpha/beta TCR reactive with glycolipids (mycobacteria) on CD1d molecules

kill tumor and viral infected cells, similar to NK cells

provide early cytokine support to antibacterial responses

19
Q

what is activated by TH1 CD4+lymphocytes? TH2 CD4+lymphocytes? TH17 CD4+lymphocyte? CTL cytotoxic CD8+ T lymphocytes?

A

macrophage activation

IgE synthesis and hypersensitivity, eosinophil activation, rxn to helminths

antimicrobial release, enhanced microbial barriers, fend off fungi, proinflamammatory responses

cell-cell interaction, perforin, and initiation of apoptosis

20
Q

what are the B cell lymphocyte responses?

A

receptor mediated B cell activation

T cell independent (mainly IgM, low affinity antibodies, short lived plasma cells)/dependent antibody response (isotope switching and long-lived plasma cells)

mode of Ig production and means of polymorphism in class switching of activated B cells

21
Q

what are the functional consequences of the B cell lymphocyte response?

where are these located in the lymph node?

A

increased survival proliferation

interaction with helper T cells

responsiveness to cytokines

migration from follicle to T cell areas

follicles and medulla

22
Q

in class switching, effect of IFN gamma? TGF-B? IL-4? (IL-2,IL-4,IL-5)?

A

IgG2a or IgG3

IgA or IgG2b

IgE or IgG1

IgM

23
Q

what are the proliferation cytokines and differentiation cytokiens?

A

IL-2, IL-4, IL-5

IL-2, IL-4, IL-5, IFN-gamma, TGF-Beta

24
Q

these cells recognize infected and altered cells

they do not display surface Ig’s

carry same cytoplasmic granules Tc cells and attack target cells in the same way as Tc cells using apoptotic granulyzmes

inhibitory receptor on surface of NK cells prevents action against self-cell

activated by same Th1 cytokines and responsible for killing cells not expressing MHC I

inhibitory receptor binds to MHC class marker

A

NK cell immune response

25
Q

as the opsonization of a surface antigen with Ig’s with an exposed Fc tail region to be recognized by Fc receptors on_____?

A

antigen dependent cellular cytotoxicity

macrophages, DCs, neutrophils, eosinophils, NK cells

26
Q

what are the characteristics of the initial antigenic response?

A

differs both quantitively and qualitatively

slow, sluggish, and short lived

long lag phase

IgM

27
Q

what is the secondary response?

A

prompt, powerful and prolonged

short or negligible

higher level of antibodies for a longer period

predominantly IgG

28
Q

what antibodies are produced by type A,B, AB, O?

significance?

A

IgM

IgM

none

IgM, IGG

IgM-agglutination and hemolysis (classical comp)
IgG-hemolysis (classical comp, Coombs test used)

29
Q

what is this transfusion product and reaction?

may have way too many WBCs that initiate an immune response rxn. Essentially transferring in non self nucleated WBC cells w/ MHC markers

A

WBC-Graft vs Host

30
Q

what is this transfusion product and reaction?

alloimmune destruction of platelets from megakaryote MHC markers being nucleated?

31
Q

what is this transfusion product and reaction?

anaphylaxis and allergic reactions in which the serum proteins may trigger hypersensitive rxn (IgE)

A

plasma proteins

32
Q

what is this transfusion product and reaction?

Hep C, HIV, CMV, Malaria are what kind of agents?

A

infectious agents

33
Q

what are hemolytic diseases of newborns called?

A

hemolytic disease of newborn

34
Q

what are the mechanism that mediate development of tolerance?

A

T cell anergy

apoptosis

regulatory cells (forehead box)

35
Q

MHC class I?

36
Q

MHC class II?

A

DP, DQ, DR

37
Q

MHCI class III?

38
Q

how do we tissue type?

A

microcytotoxicity assay (known AB)
mixed lymphocyte culture (irradiated)
flow cytometry cross typing
DNA analysis

39
Q

test to prevent transplant rejection?

A
  • ABO blood typing
  • tissue typing
  • lymphocytotoxicity
  • mixed leukocyte (irradiated-may prolif CD4, radiolabeled-may prolif CD8)
  • screening for presence
  • cross matching
40
Q

what is this type of transplant rejection?

minutes to hours
preexisting circulating Abs
intravascular thrombosis

A

hyper acute rejection

41
Q

what is this type of transplant rejection?

days to weeks
CD8 and CD4 Th1 trigger inflammation
vascular alloreactive IgG development triggers immune response
endothelialitis

A

acute rejection

42
Q

what is this type of transplant rejection?

6 mo to years
CD4 Th1 release cytokines that cause smooth muscle proliferation and vessel occlusion. CD8, macrophage damage chronic Delayed Type hypersensitivity IV reaction in vessel wall

chronic fibrosis, accelerated atherosclerosis, and loss of organ function

A

chronic rejection

43
Q

what is an example of passive immunotherapy?

A

monoclonal Abs against tumor cells and growth factor

44
Q

what is an example of adoptive cellular therapy?

other examples?

A

T cell lymphocyte reintroduction

chimeric Ag receptor to get a person to produce cancer cell cytotoxic activity

blocking normal inhibitory immune signals

T cell activating cytokines

KSUCPM MEDMICRO (52 decks)

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