MODULE IV PART II Flashcards
induction of mast cell degranulation and mediator synthesis via _____? what does this lead to production of?
arachidonic acid
leukotriene
prostaglandin
platelet activating factor
what is the effect of degranulation?
increased vascular permeability because of a hypersensitivity reaction
what is the result of histamine release?
wheal and flare or urticaria
what is the most likely result of a TIH reaction?
systemic anaphylaxis
signs and symptoms of anaphylaxis?
swelling of lips heart and vasculature respiratory skin GI
what requires emergency treatment as a result of TIH?
asthma and anaphylactic shock
how is TIH treated?
antihistamines corticosteroid and bronchodilator epinephrine -relaxes -reduces -asthma and shock
which hypersensitivity reaction is cytotoxic?
TIIH
what are some examples of TIIH?
autoimmune hemolytic anemia purpura goodpastures syndrome graves myasthenia gravis pemphigus vulgaris pernicious anemia rheumatic fever
what hypersensitivity is immune complex related?
TIIIH
what are the examples of TIIIH?
systemic lupus erythematosus
polyarteritis nodosa
post-streptococcal glomerulonephritis
serum sickness
arthus reaction
this type of TIIIH is triggered by non-gonoccoal urethritis, with extra articular features being conjunctivitis and urethritis
reactive arthritis or Reuters syndrome
what are some environment antigens that can cause a TIIIH reaction?
farmers lung disease
saung takers disease
winemakers lung
how are TIIIH reactions treated?
anti inflammatories
immunosuppressives
cell mediated reactions and T cells are what type of hypersensitivity?
TIVH
