BACTERIAL ENDOTOXIN MODE OF ACTION

Question 1

this produces effects when large number of cells grow in the body, especially when they gain access to blood stream?

Answer 1

bacterial effects

Question 2

these are the physiologic effects bacterial endotoxin?

Answer 2

fever, shock, inflammation, coagulation

Interleukin-1, Bradykinin, NO, alternative pathway of complement (C3a, C5a), activation of Hageman factor

Question 3

what is the mode of action of the Endotoxin (lipid A)?

Answer 3

activates macrophages

activates complement

activates tissue factor

Question 4

in the activation of macrophages, what happens?

Answer 4

IL-1/IL-6 (fever)
TNF (fever and hypotension)
Nitric Oxide (hypotension)

Question 5

in the activation of complement?

Answer 5

C3a (hypotension, edema)

C5a (neutrophil chemotaxis)

Question 6

in the activation of tissue factor?

Answer 6

coagulation cascade (DIC)

Question 7

bacterial endotoxin is a complement of gram negative or gram positives.

Answer 7

gram negative