sleep medicine 1, 2, 3 Flashcards

1
Q

define what sleep is

A

distinct neurological state when organisms are unaware of its surroundings

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2
Q

what are the two signs to show animals are sleeping

A

dropping abdomen and drooping antennae

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3
Q

what are the three distinct states of brain activity

A
  1. wakefullness
  2. slow wave sleep NREM
  3. REM sleep also called paradoxical
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4
Q

what is the characterisation of slow wave sleep

A

the brain is tuned down and eyes are shut, unaware of our surroundings. the motor system is awake

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5
Q

what distinct stage of sleep do most parasomnias occur in

A

NREM

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6
Q

what happens during REM seep

A

the cortex is same activity as when awake but we are not aware of our surroundings, if you awake during REM you can report dreams.

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7
Q

what stage of sleep are you paralysed

A

REM

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8
Q

why are you paralysed in REM sleep

A

inhibition of the descending alpha motor neurones

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9
Q

what is lucid dreaming

A

halfway between REM and wakefulness

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10
Q

what is sleep paralysis

A

wake up from REM unable to move, paralysis is still present and motor system is not in wakefulness yet

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11
Q

slow-wave sleep has what amplitude

A

high amplitude

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12
Q

what are the four stages of NREM sleep

A
  1. drowsiness
  2. light sleep
  3. deeper sleep
  4. deepest sleep
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13
Q

what stage of NREM sleep is the first proper stage of sleep

A

light sleep (2)

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14
Q

why is NREM sleep low frequency with high amplitude

A

because the cells are synchronised cell firing

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15
Q

why is REM sleep high frequency with low amplitude

A

because the cells are desynchronised cell firing

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16
Q

How can you tell if someone is in REM sleep?

A

rapid eye movements

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17
Q

what is skeletal muscle paralysis caused by

A

inhibition of descending alpha Motor neurones

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18
Q

is sleep voluntary or involuntary

A

voluntary because we decide when to sleep. However, extreme sleep deprivation sleep is then involuntary

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19
Q

what is the 3 process system that makes us sleep

A
  1. homeostatic
  2. circadian
  3. ultradian
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20
Q

what is sleep propensity

A

the pressure to sleep

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21
Q

why do we wake up?

A

due to decrease homeostatic and circadian pressure

22
Q

what prevents the body from recouping from missed sleep

A

body clock

23
Q

how many hours on average do we spend in REM sleep

A

1-2 hours

24
Q

how many hours on average do we spend in light sleep

A

2

25
Q

what can sleep disorders be categorised by

A
  1. disorders of initiating and maintaining sleep DIMS
  2. disorders of excessive sleepiness DOES
  3. parasomnias
  4. circadian rhythm disturbances
26
Q

what are the two categories of DIMS

A

acute or chronic

27
Q

what are examples of DIMS

A

insomnia, depression, poor sleep hygiene, drug induced, fatal familial insomnia

28
Q

what is fatal familial insomnia

A

very rare inherited condition, related to mad cow disease. Develops insomnia in teens and then die by mid 20’s

29
Q

what are examples of things that cause poor sleep hygiene

A

phones, tv, electronic distractions

30
Q

what are the examples of primary DOES

A

narcolepsy, cerebral injury, idiopathic hypersomnolence

31
Q

primary DOES are related too

A

related to brain disorders

32
Q

what is idiopathic hypersomnolence

A

naturally sleep people

33
Q

what is narcolepsy

A

an autoimmune disorder that causes a lack of orexin producing cells. this causes switches from REM to NREM = disrupted sleep

34
Q

what are the four main symptoms of narcolepsy

A
  1. irresistible sleepiness
  2. cataplexy
  3. hypnagogic hallucinations
  4. sleep paralysis
35
Q

what is cataplexy

A

motor inhibition of REM sleep, the patient is completely awake but there is sudden muscle weakness

36
Q

what are examples of secondary DOES

A
  1. obstructive sleep apnoea
  2. central sleep apnoea
  3. limb movement disorders
37
Q

obstructive sleep apnoea can cause

A

hypertension, MI, stroke, diabetes

38
Q

how does a person with obstructive sleep apnoea wake up

A

person struggles to breath, rising Co2 and lowering O2 causes the person to wake up

39
Q

what is bruxism

A

a type of parasomnia, teeth grinding

40
Q

what are examples of circadian rhythm disorders

A
  1. delayed sleep phase syndrome
  2. advanced sleep phase syndrome
  3. non-entrained circadian rhythm
41
Q

all teenagers experience what type of circadian rhythm disorder

A

delayed sleep phase syndrome

42
Q

what type of circadian rhythm disorder do the elderly experience

A

advanced sleep phase syndrome

43
Q

what do we look at when assessing sleep

A

duration, quality, architecture, associated phenomena

44
Q

how can we assess sleep duration

A
  1. sleep dairy
  2. actigraphy
  3. polysomnography
45
Q

limitations with sleep diaries

A

moderately objective, sleep often underestimated

46
Q

what is actigraphy

A

recording of movement when someone is sleeping, prolonged for around 6 weeks

movement = wakeful

little movement = sedated

no movement = sleep

47
Q

what is polysmnography

A

recording of physiological variables: EEG, EOG, EMG, ECG and body movement

48
Q

how can you record respiratory polysomnography

A

chest wall movement
air flow
airway pressures

49
Q

how can you record cardiovascular polysomnography

A

heart rate, heart variability, blood pressure

50
Q

how to assess wakefulness

A

questionnaires, multiple sleep latency, multiple wakefulness, vigilance testing

51
Q

what is the Epworth sleepiness scale

A

likelihood of falling asleep in 8 common situations

normal people: 2-10
insomnia : 0-6
narcolepsy: 13-23

52
Q

what are examples of combination tests for assessment of sleep

A

Berlin sleep apnoea questionnaire

Pittsburgh sleep quality index