NICE single technology appraisal

Question 1

when are technology appraisals needed

Answer 1

for the use of new and existing medicines

Question 2

what are the 3 forms of technology appraisals

Answer 2

1. single technology appraisal
2. fast track appraisal
3. multiple technology appraisal

Question 3

what is single technology appraisal

Answer 3

covers single technology for a single indication for example 40-49 weeks

Question 4

what is a fast track appraisal

Answer 4

covers single technology but with a shorter process time to speed up access to cost effective drugs

Question 5

what is multiple appraisal

Answer 5

covers more than one technology for a longer indication 47-60 weeks

Question 6

how do NICE classify recommendations for technology appraisals

Answer 6

1. recommended
2. optimised
3. only in research
4. not recommended
5. recommended for use in cancer drugs fund

Question 7

what is the cancer drugs fund

Answer 7

the criteria for routine comlsslon despite remaining clinical uncertainty. The committee must decide if criteria Is met :
1. likely cost - effective at current price

2. further data collection will reduce clinical uncertainty
3. ongoing studies provide useful data
4. treatment is feasible

Question 8

venetoclax is used to treat

Answer 8

chronic lymphocytic leukaemia

Question 9

what does chronic lymphocytic leukaemia

Answer 9

anaemia, swollen lymph nodes, spleen enlargement, unexplained weight loss

Question 10

an individual is defined as ‘high risk’ if they have

Answer 10

1. TP53 mutation
2. 17p deletion
3. diseases relapses after chemotherapy

Question 11

how does venetoclax works

Answer 11

selective small molecule Inhibitor of B- cell lymphoma 2 , anti-apoptotic protein overexpressed

Question 12

how is venetoclax market authorised

Answer 12

in the absence of MD deletion /TP53 mutation in adults who have failed chemo - immunotherapy and a B- cell receptor
pathway inhibitor