principles of early drug discovery Flashcards
1
Q
new drugs must represent what over standard of care
A
significant advantage
2
Q
what are the negatives of small molecule drug discovery
A
long, complex and high-risk process
3
Q
what percentage of studies fail in small molecule drug discovery
A
80-90%
4
Q
what are the stages of drug discovery
A
target ID target validation HIT generation HIT to lead lead optimisation preclinical profiling
5
Q
what is preclinical profiling
A
do candidates meet or surpass the criteria set, target potency and selectivity and human dose prediction
6
Q
why do small molecule drug discovery projects fail
A
- lack of efficacy
- lack of coherent biomarker strategy
- patient care and QoL
- toxicity
7
Q
how can AI impact drug discovery
A
- predict the activity of the drug
- predict the drug design in 3d
- drug repurposing
8
Q
how to improve productivity in drug research
A
design better disease models, develop biomarker to support target engagement, work with clinicians to understand patient needs and clinical design
