Choronodisruption Flashcards
Shift work is associated with what types of cancers
Ovarian, lung and breast cancer
The longer the circadian rthym is broken has what consequence
Higher the cancer risk
How did one discover the relationship between shift work and circadian rhythm?
Exposure to the agent
Studies of cancer in humans
Studies of cancer in experimental animals
Mechanistic evidence
How many hallmarks are needed to cause cancer
6
What are the 6 main cancer hallmarks affected by the circadian clocks
- Sustaining proliferative signalling
- Deregulating cellular epigenetics
- Resisting cell death
- Genome instability and mutation
- Activating invasion and metastasis
- Tumour promoting inflammation
Does circadian disruption accelerate cancer progression
Yes
How can jet lag increase risk of liver cancinogenesis
- For example jet lag
- Affects neuroendocrine dysfunction
- Disrupts the liver
- Leads to hyperactivatiom of CAR
If they have fatty liver it can also increase chance of liver cancer like a double wammy
How can jet lag increase risk of lung carcinogenesis
- Jet lag leads to tumour induction
2. Disrupting the light dark cycle can alter the tumour autonomous
Do tumours have clocks
Yes and no there is varability
Can you evaluate the clock inside of a tumour in a patient
Yes but it is tricky
Social jet lag is
The need to get up at a certain time for example school. This is ur biological clock vs ur alarm clock
The social jetlag had what type of effect on the pandemic
Positive
How can Social jet lag affect cancer
It can cause misalignment and progression of breast cancer
Consequences of circadian disruption
Panic attack, childhood obesity, anxiety, irritability, insufficient sleep, seasonal affective disorder, Alzheimers, breast cancer
