chronotherapy

Question 1

effects of clock disruption can cause:

Answer 1

1. mental health problems: stress, anxiety, depression
2. changes to menstrual cycle and hormone production
3. brain effects: sleep loss, reduced brain volume
4. gastrointestinal: abdominal pain, flatulence, heart burn
5. increased cancer: breast and colorectal
6. reproduction effects: low birth weight, prematurity
7. Cardiovascular: MI, hypertension

Question 2

What are the 4 stages of pharmokinetics

Answer 2

Absorption,distribution, metabolism, excreted

Question 3

Phase1 reactions are

Answer 3

Catabolic

Question 4

Phase 2 metabolism is

Answer 4

Anabolic

Question 5

how are Circadian rhythms involved during ADME

Answer 5

Gut motility, bile synthesis and excretion, liver and drug metabolism.

Question 6

Examples of Chronopharmacology drugs

Answer 6

Acetaminophene and theophylline

Question 7

When does asthma occur

Answer 7

During the later part of the night

Question 8

Paracetamol ‘s responsible for

Answer 8

Half of all acute liver failures in the us

Question 9

How is paracetamol toxic

Answer 9

Some can be converted to cytochromes p450 in the liver

Question 10

What is strongly regulated by the clock

Answer 10

Cytochromes

Question 11

Disruption to biological clocks can be treated with

Answer 11

Chronodrugs

Question 12

what is bioequivalence

Answer 12

is the biochemical similarity of two (or more) drugs that share the same active ingredient(s) and desired outcome(s) for patients