cancer trial methods Flashcards
what are the steps to cancer formation
accelerated growth division rates, deregulation of apoptosis, by damaging a Apoptic control cancer cells survive for Longer→ m utations
accumulate→ tumour progression, around 1mm is detectable at diagnosis
what are the main two parts of tumour growth
- undetectable
2. detectable
what is the undetectable part of tumour growth
when cells are growing over a period of years
what is the dectable part of tumour growth
small window between death and cure, treatment only works effectively early
what are the current cancer treatment
surgery, chemotherapy, radiotherapy, hormone therapy, immunotherapy , biological therapies, bone m arrow transplants,
how to achieve a cure
destroy/kill all cancer cells
what is prolonging survival
destroy/kill most of the cancer cella
what is the point of destorying/killing some cancer cells
eliminates systems preserves QoL
what is a complete response
disappearance of all signs of the disease
what is partial response
a reduction in tumour volume by at least 30%
what is a stable disease tumour response
no significant change
what happens during disease progression In tumour response
on increase of tumour volume by at least 20% of new metastasis
what is the overall treatment ‘survival time’
survival time from start of treatment
what is disease-free survival treatment efficacy
survival time prior to tumour relapse after radical treatment
what is progression-free survival treatment efficacy
survival time prior to tumour progression
