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Exercise Metabolism > Skeletal Muscle Energy Metabolism During Exercise W3 > Flashcards

Skeletal Muscle Energy Metabolism During Exercise W3 Flashcards

1
Q

What pumps control membrane excitability?

A

Na+ ATPase
K+ ATPase

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1
Q

What pumps control sarcoplasmic reticulum calcium handling?

A

Ca2+ ATPase

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2
Q

What pumps control myofilament cross-bridge cycling?

A

Myosin ATPase

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3
Q

What type of oxidation has a higher power output?

A

CHO

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4
Q

Where is fat oxidation maximal rate?

A

60-65%

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5
Q

What results in metabolic acidosis during intense exercise?

A

Increased ATP utilisation
Increased glycolysis
Strong ion fluxes

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6
Q

What type of muscle fibre does muscle PCr and glycogen decrease greater in during intense exercise?

A

Type II

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7
Q

What the major intramuscular and extra muscular substrates are during moderate exercise?

A

Glycogen
Blood glucose (liver glycogenolysis/ gluconeogenesis)
Fatty acids from muscle. triglycerides

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8
Q

What catalyses the PCr reaction?

A

Creatine Phosphokinase

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9
Q

What activates phosphorylase kinase?

A

Cellular Ca2+
Near by substrates and products

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10
Q

What does Cellular Ca2+ do?

A

Activates phosphorylase kinase

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11
Q

What is phosphorylase kinase?

A

Activates glycogen phosphorylase to release glycogen 1-phosphate from glycogen

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12
Q

What activates phosphorylase A?

A

Increase in ADP and AMP

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13
Q

What does Creatine Phosphokinase do?

A

Conversion of ATP and Creatine to PCr

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14
Q

What does Phosphorylase A do?

A

Breaks down glycogen
Combines Pi to Glucose-1-phosphate, Glucose-6-phosphate and fructose 6-phosphate

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15
Q

What is enzyme phosphofructokinase?

A

Regulatory enzyme

16
Q

What activates the enzyme phosphofructokinase?

A

Increase in allosteric regulators AMP/ADP/pi

17
Q

What is AMPK?

A

Sensory of muscle energy change
Glycogen levels
Muscle Glucose uptake
Fat oxidation

18
Q

What does AMPK mediate change in?

A

GLUT 4 expression
Mitochondrial biogenesis

19
Q

What increases the form of PDH into its active form?

A

Exercise regulators Ca2+
Pyruvate

20
Q

If pyruvate, CoA and NAD+ are present, flux can occur even when there is an increase in what?

A

Acetyl-CoA
NADH

21
Q

What keeps PDH inactive?

A

Resting levels of:
Acetyl-CoA
NADH

22
Q

What differences is their in metabolism between sexes?

A

Haemoglobin Concentrations
Muscle Mass
Reproductive Hormone

23
Q

What similarities is their in metabolism between sexes?

A

Fat oxidation
Fibre-type composition
Muscle Enzyme Activity

24
Q

What do females have a higher proportion in?

A

Type I fibres
Lower Maximal capacity of glycolytic enzymes
Greater reliance on IMTG during exercise

Exercise Metabolism (36 decks)

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