Skeletal Muscle Energy Metabolism During Exercise W3 Flashcards
What pumps control membrane excitability?
Na+ ATPase
K+ ATPase
What pumps control sarcoplasmic reticulum calcium handling?
Ca2+ ATPase
What pumps control myofilament cross-bridge cycling?
Myosin ATPase
What type of oxidation has a higher power output?
CHO
Where is fat oxidation maximal rate?
60-65%
What results in metabolic acidosis during intense exercise?
Increased ATP utilisation
Increased glycolysis
Strong ion fluxes
What type of muscle fibre does muscle PCr and glycogen decrease greater in during intense exercise?
Type II
What the major intramuscular and extra muscular substrates are during moderate exercise?
Glycogen
Blood glucose (liver glycogenolysis/ gluconeogenesis)
Fatty acids from muscle. triglycerides
What catalyses the PCr reaction?
Creatine Phosphokinase
What activates phosphorylase kinase?
Cellular Ca2+
Near by substrates and products
What does Cellular Ca2+ do?
Activates phosphorylase kinase
What is phosphorylase kinase?
Activates glycogen phosphorylase to release glycogen 1-phosphate from glycogen
What activates phosphorylase A?
Increase in ADP and AMP
What does Creatine Phosphokinase do?
Conversion of ATP and Creatine to PCr
What does Phosphorylase A do?
Breaks down glycogen
Combines Pi to Glucose-1-phosphate, Glucose-6-phosphate and fructose 6-phosphate