Myogenic Pathways W6

Question 1

What is the Akt/mTOR pathway?

Answer 1

Master network regulating skeletal muscle growth
Akt activated signals mTOR

Question 2

What are the 3 myogenic pathways?

Answer 2

MAPK
Akt/mTOR pathway
Ca2+

Question 3

What does Akt inhibit?

Answer 3

Catabolic signals

Question 4

What does Akt effect?

Answer 4

Anabolic signalling

Question 5

What does mTOR do?

Answer 5

Promotes hypertrophy by effecting various downstream targets

Question 6

What is the MAPK pathway?

Answer 6

Master regulator of gene expression, Redox status and metabolism

Question 7

What adaptative responses does this pathway link cellular stress with?

Answer 7

Myocytes
Modulating Growth
Differentiation

Question 8

What are the 3 distinct MAPK signalling modules linked with muscle hypertrophy?

Answer 8

ERK1/2
p38 MAPK
JNK

Question 9

What factors influence ERK1/2, p38 MAPK, JNK?

Answer 9

Responsive to mechanical tenson and muscle damage
Sensitive to eccentric exercise

Question 10

What can ERK1/2, p38MAPK, JNK cause?

Answer 10

Rapid rise in mRNA of transcription factors that modulate cell proliferation and DNA repair

Question 11

What is the Ca2+ pathway?

Answer 11

Critical regulator in the Ca2+ pathway signalling cascade

Question 12

What muscle fibres does the Ca2+ pathway allow hypertrophy to occur in?

Answer 12

All of them

Question 13

What does Ca2+ pathway mediate?

Answer 13

Myocyte enhancing factor 2
GATA transcription factors
Nuclear factor of activated T-Cells