Physical Activity and Lipoprotein Metabolism W8 Flashcards
When is APO B100 formed?
When fats are not oxidised
What is APO B100 redistributed as after being used in the liver?
VLDL particle
What does LPL do after there is circulating TAG after eating?
Cleans the fat
How is most consumed fat repackaged in the intestine wall?
Via chylomicrons
What is CETP?
Cholesteryl ester transfer protein
How does TAG leave VLDL and cholesterol re-enters VLDL?
CETP protein
What catabolises HDL in VLDLs?
Kidney
What does catabolising HDL in VLDLS do?
Prevents protection
What does TAG-rich VLDLs unload TAG onto?
HDLs
LDLS
What does TAG/TG mean?
Triacylglycerol
How does TAG-rich VDL effect lipoprotein profiles?
Increases VLDL= Increases cholesterol content= increases delivery of cholesterol to vessel walls
What does postprandial mean?
Following a meal
What does lipaemia mean?
Presence of excess lipids in blood
What is postprandial lipaemia?
The elevation of lipid in the circulation seen in the hours after eating a fat-containing meal
Where is cardiac output redistribution greatest in?
Liver and muscle
What reduces TAG after a moderate-fat meal?
Brisk walk
What mechanisms drive a reduction in TAG response?
Greater LPL activity to restore intramuscular TAG
Less hepatic VLDL secretion as more fat is being oxidised
Greater blood flow to previously exercised muscle and the liver
When can VLDL be transferred to HDL?
TAG is cleared from VLDL by lipoprotein lipase
How does training effect lipoprotein lipase activity in skeletal muscle and adipose tissue?
Increases it
What does increased lipoprotein lipase activity result in?
Improved delivery of FFA to active muscle
Improved clearance of circulating triglycerides (postprandial)
What does HSL do to assist insulin and lipid storage/transport?
Break down stored triacylglycerol in the adipocytes and re-distribute back into the blood stream
Does training increase or decrease LCAT?
Increase
What is LCAT?
Converts free cholesterols into cholesterol esters
Does training increase or decrease CETP?
Decrease
