Physical Activity and Lipoprotein Metabolism W8

Question 1

When is APO B100 formed?

Answer 1

When fats are not oxidised

Question 2

What is APO B100 redistributed as after being used in the liver?

Answer 2

VLDL particle

Question 3

What does LPL do after there is circulating TAG after eating?

Answer 3

Cleans the fat

Question 4

How is most consumed fat repackaged in the intestine wall?

Answer 4

Via chylomicrons

Question 5

What is CETP?

Answer 5

Cholesteryl ester transfer protein

Question 6

How does TAG leave VLDL and cholesterol re-enters VLDL?

Answer 6

CETP protein

Question 7

What catabolises HDL in VLDLs?

Answer 7

Kidney

Question 8

What does catabolising HDL in VLDLS do?

Answer 8

Prevents protection

Question 9

What does TAG-rich VLDLs unload TAG onto?

Answer 9

HDLs
LDLS

Question 10

What does TAG/TG mean?

Answer 10

Triacylglycerol

Question 11

How does TAG-rich VDL effect lipoprotein profiles?

Answer 11

Increases VLDL= Increases cholesterol content= increases delivery of cholesterol to vessel walls

Question 12

What does postprandial mean?

Answer 12

Following a meal

Question 13

What does lipaemia mean?

Answer 13

Presence of excess lipids in blood

Question 14

What is postprandial lipaemia?

Answer 14

The elevation of lipid in the circulation seen in the hours after eating a fat-containing meal

Question 15

Where is cardiac output redistribution greatest in?

Answer 15

Liver and muscle

Question 16

What reduces TAG after a moderate-fat meal?

Answer 16

Brisk walk

Question 17

What mechanisms drive a reduction in TAG response?

Answer 17

Greater LPL activity to restore intramuscular TAG

Less hepatic VLDL secretion as more fat is being oxidised

Greater blood flow to previously exercised muscle and the liver

Question 18

When can VLDL be transferred to HDL?

Answer 18

TAG is cleared from VLDL by lipoprotein lipase

Question 19

How does training effect lipoprotein lipase activity in skeletal muscle and adipose tissue?

Answer 19

Increases it

Question 20

What does increased lipoprotein lipase activity result in?

Answer 20

Improved delivery of FFA to active muscle
Improved clearance of circulating triglycerides (postprandial)

Question 21

What does HSL do to assist insulin and lipid storage/transport?

Answer 21

Break down stored triacylglycerol in the adipocytes and re-distribute back into the blood stream

Question 22

Does training increase or decrease LCAT?

Answer 22

Increase

Question 23

What is LCAT?

Answer 23

Converts free cholesterols into cholesterol esters

Question 24

Does training increase or decrease CETP?

Answer 24

Decrease