Lipolysis W3 Flashcards
During HIT, how does an increase in lipolysis effect fat metabolism?
It causes it to exceed fatty acid uptake and oxidation
Causes fatty acid levels to increase
What does lipolysis inhibition increase?
Reliance on muscle glycogen
Reliance on intramuscular triglyceride
What serves as liver gluconeogenic precursors?
Alanine
Glycerol
What 3 factors effect the rate of lipolysis?
Breakdown of triglyceride
Rate of fatty acid uptake
Rate of fatty acid oxidation
What regulate adipose tissue lipolysis during exercise?
Beta-blockers
Decreased insulin
Adipose tissue blood flow
FFA/Albumin ratio
Blood glucose and Lactate
Caffeine
How does beta-blockers regulate adipose tissue lipolysis?
Inhibit mobilisation of fatty acids
How does deceased insulin regulate adipose tissue lipolysis?
Important for mobilisation of both glucose and fatty acids
Potent antilipolytic effects
Reduction allows normal increase in FFA mobilisation
How does adipose tissue blood flow regulate adipose tissue lipolysis?
Flushes out fatty acids into systemic circulation
Suitable during high exercise due to more frequent vasoconstriction of adipose tissue
How does FFA/Albumin ratio regulate adipose tissue lipolysis?
Binding ratio of FFA:Albumin important determinate of mobilisation
How does Glucose and Lactate regulate adipose tissue lipolysis?
Lactate can inhibit lipolysis
Glucose effects on insulin can influence immobilisation of FA
How does Caffeine regulate adipose tissue lipolysis?
Increase FFA levels
Stimulates mobilisation of FA
Acts as stimulus
What regulates skeletal muscle lipolysis during exercise?
Plasma FFA availability
Glucose (inhibits HSL)
ERK (Ca2+)
Beta-adrenergic stimulation via PKA
Mediated by ATGL and HSL
How does ERK regulate skeletal muscle lipolysis during exercise?
It increases muscle contraction
How does insulin effect lipolysis?
Reduces lipolysis
How does epinephrine in the alpha-adrenergic pathway?
Decreases Lipolysis
