Muscle Contraction and Energetics W1

Question 1

What mediates the transmission of the electrical impulse during neuromuscular transmission?

Answer 1

Acetylcholine

Question 2

Where is calcium released to during excitation-contraction coupling?

Answer 2

Cytoplasm

Question 3

During contractile activation, what does calcium bind to?

Answer 3

Troponin-C

Question 4

What are the ATP dependent processes in skeletal muscle?

Answer 4

Cross-bridge cycling
Sarcolemma excitability
Calcium pumping into SR

Question 5

What ATPase occurs during cross-bridge cycling?

Answer 5

Myosin ATPase

Question 6

What ATPases occur during sarcolemma excitability?

Answer 6

Na+ ATPase
K+ ATPase

Question 7

When calcium is pumped into the SR, what ATPases are important?

Answer 7

SERCA-Ca2+ ATPase

Question 8

How much ATP is in wet muscle?

Answer 8

6mmol.kg-1

Question 9

What are in the anaerobic pathways of muscle contraction?

Answer 9

Creatine Phosphate
Degradation of CHO to lactate

Question 10

What are involved in oxidative metabolism during muscle contraction?

Answer 10

Utilisation of CHO and Lipids
(minor extent proteins)

Question 11

What part of myosin hydrolyses ATP?

Answer 11

S1 subunit

Question 12

What does F-actin do?

Answer 12

Increases ATPase activity by increasing rate of ADP and Pi releasement from active site

Question 13

How does calcium control muscle contraction?