Muscle Adaptations to Interval Training W7 Flashcards
What is a master regulator of mitochondrial biogenesis?
PGC1x
What adaptation to interval training does resting muscle have?
Increased maximal activity of citrate synthase and B-HAD
Increases PDH and PGC1x protein content
What does interval training increase?
Lipid oxidation
What does interval training decrease?
CHO oxidation
Muscle glycogen utilisation
PCr hydrolysis
Glycogenolysis
Lactate accumulation
Why may lactate accumulation and glycogenolysis be reduced?
Due to increased PDH activity during exercise
What occurred when 4 weeks of endurance training was performed?
Increase:
Alpha 1/2 muscle contents subunits of Na+/K+ ATPase pump
Increase in NHE1
Decrease:
Venous K+ during exhaustive exercise
What are the signalling proteins in regulating mitochondrial biogenesis?
Tfam, SIRT1 and PGC1-alpha
What happens to substrate utilisation during HIT exercise?
Reduced
PCR degradation
Glycogenolysis
Muscle Lactate accumulation
What favours reduced activation of phosphorylase?
Increased AMP, ADP and Pi
What may cause the reductions in substrate utilisation during HIT exercise?
AMP, ADP, Pi
What intracellular signalling protein kinases are activated due to HIT?
AMPK
MAPK
CaMK
What do the signalling protein kinases do?
Change gene expression of PGC1
What is mitochondrial biogenesis?
Process by which cells increases mitochondrial numbers
